A circadian rhythm in mice that is unaffected by the period mutation at clock

D. J. Coward, S. W. Cain, M. R. Ralph

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Circadian rhythms of locomotor behavior were induced in mice using chronic d-amphetamine. The periods of the rhythms at various doses of amphetamine were unaffected by a mutation at the clock locus that lengthens circadian period. Amphetamine-induced rhythms were superimposed on the host's natural circadian rhythm that is driven by the pacemaker in the suprachiasmatic nucleus. The results demonstrate the existence of an alternative mechanism for generating circadian rhythms that does not require the activity of canonical clock genes.

Original languageEnglish
Pages (from-to)233-242
Number of pages10
JournalBiological Rhythm Research
Issue number2
Publication statusPublished - 2001
Externally publishedYes


  • Amphetamine
  • Dopamine
  • Food entrainable oscillator
  • Period
  • SCN
  • Suprachiasmatic nucleus
  • Tau

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