A century of Leptospira strain typing

Gustavo Cerqueira, Mathieu Picardeau

Research output: Contribution to journalArticleResearchpeer-review

183 Citations (Scopus)


Leptospirosis is a zoonotic disease with high mortality and morbidity rates in humans and animals throughout the world. Since the discovery of Leptospira, the causal agent of leptospirosis, a century ago, this spirochete has been isolated from the environment and a wide spectrum of animals and classified into serogroups and serovars as a function of antigenic determinants. Modern technology has greatly improved laboratory procedures, particularly those for the detection, identification and typing of epidemiologic strains. In this review, we describe classical serotyping methods, followed by a description of genotyping and post-genomic typing methods.
Original languageEnglish
Pages (from-to)760 - 768
Number of pages9
JournalInfection, Genetics and Evolution
Issue number5
Publication statusPublished - 2009
Externally publishedYes

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