Abstract
Chronic renal and vascular oxidative stress in association with an enhanced inflammatory burden are determinant processes in the development and progression of diabetic complications including cardiovascular disease (CVD), atherosclerosis and diabetic kidney disease (DKD). Persistent hyperglycaemia in diabetes mellitus increases the production of reactive oxygen species (ROS) and activates mediators of inflammation as well as suppresses antioxidant defence mechanisms ultimately contributing to oxidative stress which leads to vascular and renal injury in diabetes. Furthermore, there is increasing evidence that ROS, inflammation and fibrosis promote each other and are part of a vicious connection leading to development and progression of CVD and kidney disease in diabetes.
| Original language | English |
|---|---|
| Pages (from-to) | 1811-1836 |
| Number of pages | 26 |
| Journal | Clinical Science |
| Volume | 132 |
| Issue number | 16 |
| DOIs | |
| Publication status | Published - 1 Aug 2018 |
Cite this
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A causal link between oxidative stress and inflammation in cardiovascular and renal complications of diabetes. / Jha, Jay C.; Ho, Florence; Dan, Christopher; Jandeleit-Dahm, Karin.
In: Clinical Science, Vol. 132, No. 16, 01.08.2018, p. 1811-1836.Research output: Contribution to journal › Review Article › Research › peer-review
TY - JOUR
T1 - A causal link between oxidative stress and inflammation in cardiovascular and renal complications of diabetes
AU - Jha, Jay C.
AU - Ho, Florence
AU - Dan, Christopher
AU - Jandeleit-Dahm, Karin
PY - 2018/8/1
Y1 - 2018/8/1
N2 - Chronic renal and vascular oxidative stress in association with an enhanced inflammatory burden are determinant processes in the development and progression of diabetic complications including cardiovascular disease (CVD), atherosclerosis and diabetic kidney disease (DKD). Persistent hyperglycaemia in diabetes mellitus increases the production of reactive oxygen species (ROS) and activates mediators of inflammation as well as suppresses antioxidant defence mechanisms ultimately contributing to oxidative stress which leads to vascular and renal injury in diabetes. Furthermore, there is increasing evidence that ROS, inflammation and fibrosis promote each other and are part of a vicious connection leading to development and progression of CVD and kidney disease in diabetes.
AB - Chronic renal and vascular oxidative stress in association with an enhanced inflammatory burden are determinant processes in the development and progression of diabetic complications including cardiovascular disease (CVD), atherosclerosis and diabetic kidney disease (DKD). Persistent hyperglycaemia in diabetes mellitus increases the production of reactive oxygen species (ROS) and activates mediators of inflammation as well as suppresses antioxidant defence mechanisms ultimately contributing to oxidative stress which leads to vascular and renal injury in diabetes. Furthermore, there is increasing evidence that ROS, inflammation and fibrosis promote each other and are part of a vicious connection leading to development and progression of CVD and kidney disease in diabetes.
UR - http://www.scopus.com/inward/record.url?scp=85052875818&partnerID=8YFLogxK
U2 - 10.1042/CS20171459
DO - 10.1042/CS20171459
M3 - Review Article
VL - 132
SP - 1811
EP - 1836
JO - Clinical Science and Molecular Medicine
JF - Clinical Science and Molecular Medicine
SN - 0009-9287
IS - 16
ER -