A case-sibling assessment of the association between skin pigmentation and other vitamin d-related factors and type 1 diabetes mellitus

Anne Louise Ponsonby, Fergus Cameron, Richard Saffery, Angela Pezic, Nick Wong, Jeff Craig, Justine Ellis, Terence Dwyer

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Fair skin pigmentation has been associated with a higher risk of type 1 diabetes mellitus (T1DM). The aim is to compare children with T1DM directly to a sibling in relation to their skin pigmentation in sun-exposed and unexposed sites, past sun exposure and methylation of the VDR gene promoter. The sample consisted of children with T1DM attending a diabetes outpatient clinic and siblings (total n = 42). Cutaneous melanin density was estimated using a spectrophotometer. Parental report on past sun exposure was obtained. DNA methylation analysis of the VDR gene promoter was conducted. Matched data analysis was performed comparing each case directly to their sibling. Cases were significantly more likely to have lighter skin pigmentation at the upper arm (AOR 0.69 [95% CI: 0.52, 0.90]; P = 0.01). Low infant sun exposure was imprecisely associated with a two-fold increase in T1DM risk (AOR 2.43 [95% CI: 0.91, 6.51]; P = 0.08 for under 1 h of winter sun exposure per leisure day). The VDR gene promoter was completely unmethylated in both cases and siblings. The previously demonstrated association between light skin pigmentation and T1DM risk was evident even in this comparison across sibling pairs. Further work on past UVR exposure and related factors such as skin pigmentation is required.

Original languageEnglish
Pages (from-to)1267-1270
Number of pages4
JournalPhotochemistry and Photobiology
Volume85
Issue number5
DOIs
Publication statusPublished - 1 Sep 2009
Externally publishedYes

Cite this

Ponsonby, Anne Louise ; Cameron, Fergus ; Saffery, Richard ; Pezic, Angela ; Wong, Nick ; Craig, Jeff ; Ellis, Justine ; Dwyer, Terence. / A case-sibling assessment of the association between skin pigmentation and other vitamin d-related factors and type 1 diabetes mellitus. In: Photochemistry and Photobiology. 2009 ; Vol. 85, No. 5. pp. 1267-1270.
@article{ca12d5f5f0a24fa2bd92b6bf9b546afd,
title = "A case-sibling assessment of the association between skin pigmentation and other vitamin d-related factors and type 1 diabetes mellitus",
abstract = "Fair skin pigmentation has been associated with a higher risk of type 1 diabetes mellitus (T1DM). The aim is to compare children with T1DM directly to a sibling in relation to their skin pigmentation in sun-exposed and unexposed sites, past sun exposure and methylation of the VDR gene promoter. The sample consisted of children with T1DM attending a diabetes outpatient clinic and siblings (total n = 42). Cutaneous melanin density was estimated using a spectrophotometer. Parental report on past sun exposure was obtained. DNA methylation analysis of the VDR gene promoter was conducted. Matched data analysis was performed comparing each case directly to their sibling. Cases were significantly more likely to have lighter skin pigmentation at the upper arm (AOR 0.69 [95{\%} CI: 0.52, 0.90]; P = 0.01). Low infant sun exposure was imprecisely associated with a two-fold increase in T1DM risk (AOR 2.43 [95{\%} CI: 0.91, 6.51]; P = 0.08 for under 1 h of winter sun exposure per leisure day). The VDR gene promoter was completely unmethylated in both cases and siblings. The previously demonstrated association between light skin pigmentation and T1DM risk was evident even in this comparison across sibling pairs. Further work on past UVR exposure and related factors such as skin pigmentation is required.",
author = "Ponsonby, {Anne Louise} and Fergus Cameron and Richard Saffery and Angela Pezic and Nick Wong and Jeff Craig and Justine Ellis and Terence Dwyer",
year = "2009",
month = "9",
day = "1",
doi = "10.1111/j.1751-1097.2009.00563.x",
language = "English",
volume = "85",
pages = "1267--1270",
journal = "Photochemistry and Photobiology",
issn = "0031-8655",
publisher = "Wiley-Blackwell",
number = "5",

}

A case-sibling assessment of the association between skin pigmentation and other vitamin d-related factors and type 1 diabetes mellitus. / Ponsonby, Anne Louise; Cameron, Fergus; Saffery, Richard; Pezic, Angela; Wong, Nick; Craig, Jeff; Ellis, Justine; Dwyer, Terence.

In: Photochemistry and Photobiology, Vol. 85, No. 5, 01.09.2009, p. 1267-1270.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - A case-sibling assessment of the association between skin pigmentation and other vitamin d-related factors and type 1 diabetes mellitus

AU - Ponsonby, Anne Louise

AU - Cameron, Fergus

AU - Saffery, Richard

AU - Pezic, Angela

AU - Wong, Nick

AU - Craig, Jeff

AU - Ellis, Justine

AU - Dwyer, Terence

PY - 2009/9/1

Y1 - 2009/9/1

N2 - Fair skin pigmentation has been associated with a higher risk of type 1 diabetes mellitus (T1DM). The aim is to compare children with T1DM directly to a sibling in relation to their skin pigmentation in sun-exposed and unexposed sites, past sun exposure and methylation of the VDR gene promoter. The sample consisted of children with T1DM attending a diabetes outpatient clinic and siblings (total n = 42). Cutaneous melanin density was estimated using a spectrophotometer. Parental report on past sun exposure was obtained. DNA methylation analysis of the VDR gene promoter was conducted. Matched data analysis was performed comparing each case directly to their sibling. Cases were significantly more likely to have lighter skin pigmentation at the upper arm (AOR 0.69 [95% CI: 0.52, 0.90]; P = 0.01). Low infant sun exposure was imprecisely associated with a two-fold increase in T1DM risk (AOR 2.43 [95% CI: 0.91, 6.51]; P = 0.08 for under 1 h of winter sun exposure per leisure day). The VDR gene promoter was completely unmethylated in both cases and siblings. The previously demonstrated association between light skin pigmentation and T1DM risk was evident even in this comparison across sibling pairs. Further work on past UVR exposure and related factors such as skin pigmentation is required.

AB - Fair skin pigmentation has been associated with a higher risk of type 1 diabetes mellitus (T1DM). The aim is to compare children with T1DM directly to a sibling in relation to their skin pigmentation in sun-exposed and unexposed sites, past sun exposure and methylation of the VDR gene promoter. The sample consisted of children with T1DM attending a diabetes outpatient clinic and siblings (total n = 42). Cutaneous melanin density was estimated using a spectrophotometer. Parental report on past sun exposure was obtained. DNA methylation analysis of the VDR gene promoter was conducted. Matched data analysis was performed comparing each case directly to their sibling. Cases were significantly more likely to have lighter skin pigmentation at the upper arm (AOR 0.69 [95% CI: 0.52, 0.90]; P = 0.01). Low infant sun exposure was imprecisely associated with a two-fold increase in T1DM risk (AOR 2.43 [95% CI: 0.91, 6.51]; P = 0.08 for under 1 h of winter sun exposure per leisure day). The VDR gene promoter was completely unmethylated in both cases and siblings. The previously demonstrated association between light skin pigmentation and T1DM risk was evident even in this comparison across sibling pairs. Further work on past UVR exposure and related factors such as skin pigmentation is required.

UR - http://www.scopus.com/inward/record.url?scp=69649088282&partnerID=8YFLogxK

U2 - 10.1111/j.1751-1097.2009.00563.x

DO - 10.1111/j.1751-1097.2009.00563.x

M3 - Article

VL - 85

SP - 1267

EP - 1270

JO - Photochemistry and Photobiology

JF - Photochemistry and Photobiology

SN - 0031-8655

IS - 5

ER -