A case-control study of breast cancer risk factors in 7,663 women in Malaysia

Min Min Tan, Weang Kee Ho, Sook Yee Yoon, Shivaani Mariapun, Siti Norhidayu Hasan, Daphne Shin-Chi Lee, Tiara Hassan, Sheau Yee Lee, Sze Yee Phuah, Kavitta Sivanandan, Patsy Pei-Sze Ng, Nadia Rajaram, Maheswari Jaganathan, Suniza Jamaris, Tania Islam, Kartini Rahmat, Farhana Fadzli, Anushya Vijayananthan, Pathmanathan Rajadurai, Mee Hong SeeMeow Keong Thong, Nur Aishah Mohd Taib, Cheng Har Yip, Soo Hwang Teo

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    18 Citations (Scopus)


    Background Breast cancer risk factors have been examined extensively in Western setting and more developed Asian cities/countries. However, there are limited data on developing Asian countries. The purpose of this study was to examine breast cancer risk factors and the change of selected risk factors across birth cohorts in Malaysian women. Methods An unmatched hospital based case-control study was conducted from October 2002 to December 2016 in Selangor, Malaysia. A total of 3,683 cases and 3,980 controls were included in this study. Unconditional logistic regressions, adjusted for potential confounding factors, were conducted. The breast cancer risk factors were compared across four birth cohorts by ethnicity. Results Ever breastfed, longer breastfeeding duration, a higher soymilk and soy product intake, and a higher level of physical activity were associated with lower risk of breast cancer. Chinese had the lowest breastfeeding rate, shortest breastfeeding duration, lowest parity and highest age of first full term pregnancy. Conclusions Our study shows that breastfeeding, soy intake and physical activity are modifiable risk factors for breast cancer. With the increasing incidence of breast cancer there is an urgent need to educate the women about lifestyle intervention they can take to reduce their breast cancer risk.

    Original languageEnglish
    Article numbere0203469
    Number of pages12
    JournalPLoS ONE
    Issue number9
    Publication statusPublished - 14 Sep 2018

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