TY - JOUR
T1 - A canine model for production of severe unilateral panacinar emphysema
AU - Chino, Kimiaki
AU - Choong, Cliff Khuat Chye
AU - Toeniskoetter, Diane P
AU - Cooper, Joel
AU - Lausberg, Henning F
AU - Bae, Kyongtae T
AU - Pierce, John A
AU - Hogg, James
PY - 2004
Y1 - 2004
N2 - Animal models of disease help advance the understanding of pathogenesis
and are useful in developing and evaluating new therapeutic options.
Pulmonary emphysema has been produced previously by using various
agents in animals and by genetic interventions in rodents. These models
have helped to elucidate the pathophysiology of emphysema [1, 2]. However,
small animals are not suitable for the study of surgical procedures in
the treatment of emphysema. The present report concernsa technique of
repeated single lung lavage witha solution of porcine pancreatic elastase
to produce extreme, end-stage emphysema in a canine model.
AB - Animal models of disease help advance the understanding of pathogenesis
and are useful in developing and evaluating new therapeutic options.
Pulmonary emphysema has been produced previously by using various
agents in animals and by genetic interventions in rodents. These models
have helped to elucidate the pathophysiology of emphysema [1, 2]. However,
small animals are not suitable for the study of surgical procedures in
the treatment of emphysema. The present report concernsa technique of
repeated single lung lavage witha solution of porcine pancreatic elastase
to produce extreme, end-stage emphysema in a canine model.
UR - http://informahealthcare.com.ezproxy.lib.monash.edu.au/doi/pdf/10.1080/01902140490439022
U2 - 10.1080/01902140490439022
DO - 10.1080/01902140490439022
M3 - Article
SN - 0190-2148
VL - 30
SP - 319
EP - 332
JO - Experimental Lung Research
JF - Experimental Lung Research
IS - 4
ER -