Animal models of disease help advance the understanding of pathogenesis and are useful in developing and evaluating new therapeutic options. Pulmonary emphysema has been produced previously by using various agents in animals and by genetic interventions in rodents. These models have helped to elucidate the pathophysiology of emphysema [1, 2]. However, small animals are not suitable for the study of surgical procedures in the treatment of emphysema. The present report concernsa technique of repeated single lung lavage witha solution of porcine pancreatic elastase to produce extreme, end-stage emphysema in a canine model.