A calibrated human Y-chromosomal phylogeny based on resequencing

Wei Wei, Qasim Ayub, Yuan Chen, Shane McCarthy, Yiping Hou, Ignazio Carbone, Yali Xue, Chris Tyler-Smith

Research output: Contribution to journalArticleResearchpeer-review

105 Citations (Scopus)

Abstract

We have identified variants present in high-coverage complete sequences of 36 diverse human Y chromosomes from Africa, Europe, South Asia, East Asia, and the Americas, representing eight major haplogroups. After restricting our analysis to 8.97 Mb of the unique male-specific Y sequence, we identified 6662 high-confidence variants, including singlenucleotide polymorphisms (SNPs), multi-nucleotide polymorphisms (MNPs), and indels. We constructed phylogenetic trees using these variants, or subsets of them, and recapitulated the known structure of the tree. Assuming a male mutation rate of 1 3 10-9 per base pair per year, the time depth of the tree (haplogroups A3-R) was ~101,000-115,000 yr, and the lineages found outside Africa dated to 57,000-74,000 yr, both as expected. In addition, we dated a striking Paleolithic male lineage expansion to 41,000-52,000 yr ago and the node representing the major European Y lineage, R1b, to 4000- 13,000 yr ago, supporting a Neolithic origin for these modern European Y chromosomes. In all, we provide a nearly 10-fold increase in the number of Y markers with phylogenetic information, and novel historical insights derived from placing them on a calibrated phylogenetic tree.

Original languageEnglish
Pages (from-to)388-395
Number of pages8
JournalGenome Research
Volume23
Issue number2
DOIs
Publication statusPublished - Feb 2013
Externally publishedYes

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