Abstract
We combine methodology from history and genetics to reconstruct the biosocial history of antimicrobial resistance (AMR) in the bacterium Salmonella enterica serovar Typhi (S. Typhi). We show how evolutionary divergence in S. Typhi was driven by rising global antibiotic use and by the neglect of typhoid outside of high-income countries. Although high-income countries pioneered 1960s precautionary antibiotic regulations to prevent selection for multidrug resistance, new antibiotic classes, typhoid's cultural status as a supposedly ancient disease of "undeveloped" countries, limited international funding, and narrow biosecurity agendas helped fragment effective global collective action for typhoid control. Antibiotic-intensive compensation for weak water and healthcare systems subsequently fueled AMR selection in low- and middle-income countries but often remained invisible due to lacking surveillance capabilities. The recent rise of extensively drug-resistant typhoid bears the biosocial footprint of more than half a century of antibiotic-intensive international neglect.
| Original language | English |
|---|---|
| Pages (from-to) | S388-S394 |
| Number of pages | 7 |
| Journal | Clinical Infectious Diseases |
| Volume | 69 |
| Issue number | Supp 5 |
| DOIs | |
| Publication status | Published - 1 Nov 2019 |
| Externally published | Yes |
Keywords
- international health
- antimicrobial resistance
- biosecurity
- typhoid
- vaccination
Cite this
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A Biohistorical Perspective of Typhoid and Antimicrobial Resistance. / Kirchhelle, Claas; Dyson, Zoe Anne; Dougan, Gordon.
In: Clinical Infectious Diseases, Vol. 69, No. Supp 5, 01.11.2019, p. S388-S394.Research output: Contribution to journal › Article › Other › peer-review
TY - JOUR
T1 - A Biohistorical Perspective of Typhoid and Antimicrobial Resistance
AU - Kirchhelle, Claas
AU - Dyson, Zoe Anne
AU - Dougan, Gordon
PY - 2019/11/1
Y1 - 2019/11/1
N2 - We combine methodology from history and genetics to reconstruct the biosocial history of antimicrobial resistance (AMR) in the bacterium Salmonella enterica serovar Typhi (S. Typhi). We show how evolutionary divergence in S. Typhi was driven by rising global antibiotic use and by the neglect of typhoid outside of high-income countries. Although high-income countries pioneered 1960s precautionary antibiotic regulations to prevent selection for multidrug resistance, new antibiotic classes, typhoid's cultural status as a supposedly ancient disease of "undeveloped" countries, limited international funding, and narrow biosecurity agendas helped fragment effective global collective action for typhoid control. Antibiotic-intensive compensation for weak water and healthcare systems subsequently fueled AMR selection in low- and middle-income countries but often remained invisible due to lacking surveillance capabilities. The recent rise of extensively drug-resistant typhoid bears the biosocial footprint of more than half a century of antibiotic-intensive international neglect.
AB - We combine methodology from history and genetics to reconstruct the biosocial history of antimicrobial resistance (AMR) in the bacterium Salmonella enterica serovar Typhi (S. Typhi). We show how evolutionary divergence in S. Typhi was driven by rising global antibiotic use and by the neglect of typhoid outside of high-income countries. Although high-income countries pioneered 1960s precautionary antibiotic regulations to prevent selection for multidrug resistance, new antibiotic classes, typhoid's cultural status as a supposedly ancient disease of "undeveloped" countries, limited international funding, and narrow biosecurity agendas helped fragment effective global collective action for typhoid control. Antibiotic-intensive compensation for weak water and healthcare systems subsequently fueled AMR selection in low- and middle-income countries but often remained invisible due to lacking surveillance capabilities. The recent rise of extensively drug-resistant typhoid bears the biosocial footprint of more than half a century of antibiotic-intensive international neglect.
KW - international health
KW - antimicrobial resistance
KW - biosecurity
KW - typhoid
KW - vaccination
UR - http://www.scopus.com/inward/record.url?scp=85073179500&partnerID=8YFLogxK
U2 - 10.1093/cid/ciz556
DO - 10.1093/cid/ciz556
M3 - Article
C2 - 31612939
AN - SCOPUS:85073179500
VL - 69
SP - S388-S394
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
SN - 1058-4838
IS - Supp 5
ER -