A biodegradable multiblock co-polymer derived from an alpha, omega-bis(methylamino)peptide and an alpha, omega-bis(oxiranylmethyl)poly(ethylene glycol): J Control Release

S. E. Matthews, C. W. Pouton, M. D. Threadgill

Research output: Contribution to journalArticleResearchpeer-review

Abstract

A novel peptide containing the lysosomally degradable sequence GlyPheLeuGly and a sequence-inverting unit has been prepared. This peptide presents the methylamino groups of sarcosine (N-methylglycine) at both termini for co-polymerisation with alpha, omega-bis(oxiranylmethoxy)poly(ethylene glycol) of mean M(w) 1650. Gel permeation chromatographic analysis showed the presence of a mixture of oligomers. Preliminary degradation studies showed that these oligomers are cleaved by cathepsin B, an important lysosomal enzyme.
Original languageEnglish
Pages (from-to)129-139
Number of pages11
JournalJournal of Controlled Release
Volume67
Publication statusPublished - 2000

Keywords

  • Cathepsin B/chemistry *Drug Delivery Systems Magnetic Resonance Spectroscopy Peptides/administration & dosage/*chemical synthesis/chemistry Polyethylene Glycols/administration & dosage/*chemical synthesis/chemistry

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