A novel peptide containing the lysosomally degradable sequence GlyPheLeuGly and a sequence-inverting unit has been prepared. This peptide presents the methylamino groups of sarcosine (N-methylglycine) at both termini for co-polymerisation with alpha, omega-bis(oxiranylmethoxy)poly(ethylene glycol) of mean M(w) 1650. Gel permeation chromatographic analysis showed the presence of a mixture of oligomers. Preliminary degradation studies showed that these oligomers are cleaved by cathepsin B, an important lysosomal enzyme.
|Number of pages||11|
|Journal||Journal of Controlled Release|
|Publication status||Published - 2000|
- Cathepsin B/chemistry *Drug Delivery Systems Magnetic Resonance Spectroscopy Peptides/administration & dosage/*chemical synthesis/chemistry Polyethylene Glycols/administration & dosage/*chemical synthesis/chemistry
Matthews, S. E., Pouton, C. W., & Threadgill, M. D. (2000). A biodegradable multiblock co-polymer derived from an alpha, omega-bis(methylamino)peptide and an alpha, omega-bis(oxiranylmethyl)poly(ethylene glycol): J Control Release. Journal of Controlled Release, 67, 129-139. http://www.ncbi.nlm.nih.gov/pubmed/10825548