A biodegradable multiblock co-polymer derived from an α,ω-bis(methylamino)peptide and an α,ω-bis(oxiranylmethyl)poly(ethylene glycol)

Susan E. Matthews, Colin W. Pouton, Michael D. Threadgill

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12 Citations (Scopus)

Abstract

A novel peptide containing the lysosomally degradable sequence GlyPheLeuGly and a sequence-inverting unit has been prepared. This peptide presents the methylamino groups of sarcosine (N-methylglycine) at both termini for co-polymerisation with α,ω-bis(oxiranylmethoxy)poly(ethylene glycol) of mean M(w) 1650. Gel permeation chromatographic analysis showed the presence of a mixture of oligomers. Preliminary degradation studies showed that these oligomers are cleaved by cathepsin B, an important lysosomal enzyme. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)129-139
Number of pages11
JournalJournal of Controlled Release
Volume67
Issue number2-3
DOIs
Publication statusPublished - 3 Jul 2000

Keywords

  • Biodegradable
  • Cathepsin B
  • GlyPheLeuGly
  • Polyethylene glycol
  • Retro-inverso peptide

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