A bio-inspired potassium and pH responsive double-gated nanochannel

Meiying Liu, Huacheng Zhang, Kan Li, Liping Heng, Shutao Wang, Ye Tian, Lei Jiang

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59 Citations (Scopus)


Bio-inspired nanochannels have emerged as an interface to mimic the functionalities of biological nanochannels. One remaining challenge is to develop double-gated nanochannels with dual response, which can regulate the ion transport direction by alternately opening and closing the two gates. In this work, a bio-inspired potassium and pH responsive double-gated nanosystem is presented, constructed through immobilizing C-quadruplex and G-quadruplex DNA molecules onto the top and bottom tip side of a cigar-shaped nanochannel, respectively. It is demonstrated that the two gates of the nanochannel can be opened and closed alternately/simultaneously. This phenomenon results from the attached DNA conformational transition caused by adjusting the concentrations of potassium ion and proton. This design is believed to be the first example of dual-responsive double-gated nanosystem, and paves a new way to investigate more intelligent bio-inspired nanofluidic system.
Original languageEnglish
Pages (from-to)421-426
Number of pages6
JournalAdvanced Functional Materials
Issue number3
Publication statusPublished - 21 Jan 2015
Externally publishedYes

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