A biased view toward celiac disease

Jamie Rossjohn; Frits Koning

doi:10.1038/mi.2016.17

A biased view toward celiac disease

Jamie Rossjohn
, Frits Koning

Biochemistry & Molecular Biology

Research output: Contribution to journal › Letter › Other

6 Citations (Scopus)

Abstract

Celiac disease is an autoimmune-like disorder that is triggered by dietary gluten and has a strong genetic association with the human leukocyte antigen locus, specifically, HLA-DQ2.5/DQ8. Here, Dahai-Koirala et al. apply ex vivo single-cell sequencing of TCRs from celiac disease patients, and show that biased T-cell receptor usage underpins the response to two gluten epitopes, which has implications for disease pathogenesis, diagnosis, and treatment.Mucosal Immunology advance online publication, 23 March 2016; doi:10.1038/mi.2016.17.

Original language	English
Pages (from-to)	583 - 586
Number of pages	4
Journal	Mucosal Immunology
Volume	9
Issue number	3
DOIs	https://doi.org/10.1038/mi.2016.17
Publication status	Published - 2016

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1038/mi.2016.17

Cite this

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title = "A biased view toward celiac disease",

abstract = "Celiac disease is an autoimmune-like disorder that is triggered by dietary gluten and has a strong genetic association with the human leukocyte antigen locus, specifically, HLA-DQ2.5/DQ8. Here, Dahai-Koirala et al. apply ex vivo single-cell sequencing of TCRs from celiac disease patients, and show that biased T-cell receptor usage underpins the response to two gluten epitopes, which has implications for disease pathogenesis, diagnosis, and treatment.Mucosal Immunology advance online publication, 23 March 2016; doi:10.1038/mi.2016.17.",

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AU - Koning, Frits

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AB - Celiac disease is an autoimmune-like disorder that is triggered by dietary gluten and has a strong genetic association with the human leukocyte antigen locus, specifically, HLA-DQ2.5/DQ8. Here, Dahai-Koirala et al. apply ex vivo single-cell sequencing of TCRs from celiac disease patients, and show that biased T-cell receptor usage underpins the response to two gluten epitopes, which has implications for disease pathogenesis, diagnosis, and treatment.Mucosal Immunology advance online publication, 23 March 2016; doi:10.1038/mi.2016.17.

UR - http://www.ncbi.nlm.nih.gov/pubmed/27007675

U2 - 10.1038/mi.2016.17

DO - 10.1038/mi.2016.17

M3 - Letter

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VL - 9

SP - 583

EP - 586

JO - Mucosal Immunology

JF - Mucosal Immunology

IS - 3

ER -

A biased view toward celiac disease

Abstract

UN SDGs

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