A biased view toward celiac disease

Jamie Rossjohn, Frits Koning

Research output: Contribution to journalLetterOther

5 Citations (Scopus)

Abstract

Celiac disease is an autoimmune-like disorder that is triggered by dietary gluten and has a strong genetic association with the human leukocyte antigen locus, specifically, HLA-DQ2.5/DQ8. Here, Dahai-Koirala et al. apply ex vivo single-cell sequencing of TCRs from celiac disease patients, and show that biased T-cell receptor usage underpins the response to two gluten epitopes, which has implications for disease pathogenesis, diagnosis, and treatment.Mucosal Immunology advance online publication, 23 March 2016; doi:10.1038/mi.2016.17.
Original languageEnglish
Pages (from-to)583 - 586
Number of pages4
JournalMucosal Immunology
Volume9
Issue number3
DOIs
Publication statusPublished - 2016

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