A BAT-centric approach to the treatment of diabetes: Turn on the brain

Mohammed K. Hankir; Michael A. Cowley; Wiebke K. Fenske

doi:10.1016/j.cmet.2016.05.003

A BAT-centric approach to the treatment of diabetes: Turn on the brain

Mohammed K. Hankir, Michael A. Cowley, Wiebke K. Fenske

Physiology

Research output: Contribution to journal › Review Article › Other › peer-review

33 Citations (Scopus)

Abstract

The marked (18)F-flurodeoxyglucose uptake by brown adipose tissue (BAT) enabled its identification in human positron emission tomography imaging studies. In this Perspective, we discuss how glucose extraction by BAT and beige adipose tissue (BeAT) sufficiently impacts on glycemic control. We then present a unique overview of the central circuits modulated by gluco-regulatory hormones, temperature, and glucose itself, which converge on sympathetic preganglionic neurons and whose activation syphon circulating glucose into BAT/BeAT. Targeted stimulation of the sympathetic nervous system at specific nodes to selectively recruit BAT/BeAT may represent a safe and effective means of treating diabetes.

Original language	English
Pages (from-to)	31-40
Number of pages	10
Journal	Cell Metabolism
Volume	24
Issue number	1
DOIs	https://doi.org/10.1016/j.cmet.2016.05.003
Publication status	Published - 12 Jul 2016

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SDG 3 Good Health and Well-being

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10.1016/j.cmet.2016.05.003

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title = "A BAT-centric approach to the treatment of diabetes: Turn on the brain",

abstract = "The marked (18)F-flurodeoxyglucose uptake by brown adipose tissue (BAT) enabled its identification in human positron emission tomography imaging studies. In this Perspective, we discuss how glucose extraction by BAT and beige adipose tissue (BeAT) sufficiently impacts on glycemic control. We then present a unique overview of the central circuits modulated by gluco-regulatory hormones, temperature, and glucose itself, which converge on sympathetic preganglionic neurons and whose activation syphon circulating glucose into BAT/BeAT. Targeted stimulation of the sympathetic nervous system at specific nodes to selectively recruit BAT/BeAT may represent a safe and effective means of treating diabetes.",

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T2 - Turn on the brain

AU - Hankir, Mohammed K.

AU - Cowley, Michael A.

AU - Fenske, Wiebke K.

PY - 2016/7/12

Y1 - 2016/7/12

N2 - The marked (18)F-flurodeoxyglucose uptake by brown adipose tissue (BAT) enabled its identification in human positron emission tomography imaging studies. In this Perspective, we discuss how glucose extraction by BAT and beige adipose tissue (BeAT) sufficiently impacts on glycemic control. We then present a unique overview of the central circuits modulated by gluco-regulatory hormones, temperature, and glucose itself, which converge on sympathetic preganglionic neurons and whose activation syphon circulating glucose into BAT/BeAT. Targeted stimulation of the sympathetic nervous system at specific nodes to selectively recruit BAT/BeAT may represent a safe and effective means of treating diabetes.

AB - The marked (18)F-flurodeoxyglucose uptake by brown adipose tissue (BAT) enabled its identification in human positron emission tomography imaging studies. In this Perspective, we discuss how glucose extraction by BAT and beige adipose tissue (BeAT) sufficiently impacts on glycemic control. We then present a unique overview of the central circuits modulated by gluco-regulatory hormones, temperature, and glucose itself, which converge on sympathetic preganglionic neurons and whose activation syphon circulating glucose into BAT/BeAT. Targeted stimulation of the sympathetic nervous system at specific nodes to selectively recruit BAT/BeAT may represent a safe and effective means of treating diabetes.

UR - https://www.scopus.com/pages/publications/84992332899

U2 - 10.1016/j.cmet.2016.05.003

DO - 10.1016/j.cmet.2016.05.003

M3 - Review Article

AN - SCOPUS:84992332899

SN - 1550-4131

VL - 24

SP - 31

EP - 40

JO - Cell Metabolism

JF - Cell Metabolism

IS - 1

ER -

A BAT-centric approach to the treatment of diabetes: Turn on the brain

Abstract

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