A balancing act: PHLPP2 fine tunes AKT activity and MYC stability in prostate cancer

Roxanne Toivanen; Luc Furic

doi:10.1083/jcb.201904119

A balancing act: PHLPP2 fine tunes AKT activity and MYC stability in prostate cancer

Roxanne Toivanen, Luc Furic

Research output: Contribution to journal › Editorial › Other › peer-review

Abstract

PTEN loss stimulates prostate tumor progression by sustaining AKT activation. Nowak et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201902048) surprisingly show that the AKT-suppressing phosphatase PHLPP2 promotes disease progression in the context of dual PTEN and p53 loss by increasing MYC stability.

Original language	English
Pages (from-to)	1771-1772
Number of pages	2
Journal	Journal of Cell Biology
Volume	218
Issue number	6
DOIs	https://doi.org/10.1083/jcb.201904119
Publication status	Published - 3 Jun 2019

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10.1083/jcb.201904119

1 Curtailed
1 Finished

Targeting MYC driven PC by combining targeted radionuclide therapy with ribosome biogenesis inhibition as a new therapy in CRPC and neuroendocrine PC
Furic, L.
1/01/17 → 31/12/21
Project: Research
Investigating the origins of neuroendocrine prostate cancer
Toivanen, R., Risbridger, G., Taylor, R., Goode, D., Clouston, D. & Murphy, D. G.
15/02/19 → 4/03/22
Project: Research

Cite this

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title = "A balancing act: PHLPP2 fine tunes AKT activity and MYC stability in prostate cancer",

abstract = "PTEN loss stimulates prostate tumor progression by sustaining AKT activation. Nowak et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201902048) surprisingly show that the AKT-suppressing phosphatase PHLPP2 promotes disease progression in the context of dual PTEN and p53 loss by increasing MYC stability.",

author = "Roxanne Toivanen and Luc Furic",

year = "2019",

month = jun,

day = "3",

doi = "10.1083/jcb.201904119",

language = "English",

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journal = "Journal of Cell Biology",

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number = "6",

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T1 - A balancing act

T2 - PHLPP2 fine tunes AKT activity and MYC stability in prostate cancer

AU - Toivanen, Roxanne

AU - Furic, Luc

PY - 2019/6/3

Y1 - 2019/6/3

N2 - PTEN loss stimulates prostate tumor progression by sustaining AKT activation. Nowak et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201902048) surprisingly show that the AKT-suppressing phosphatase PHLPP2 promotes disease progression in the context of dual PTEN and p53 loss by increasing MYC stability.

AB - PTEN loss stimulates prostate tumor progression by sustaining AKT activation. Nowak et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201902048) surprisingly show that the AKT-suppressing phosphatase PHLPP2 promotes disease progression in the context of dual PTEN and p53 loss by increasing MYC stability.

U2 - 10.1083/jcb.201904119

DO - 10.1083/jcb.201904119

M3 - Editorial

SN - 0021-9525

VL - 218

SP - 1771

EP - 1772

JO - Journal of Cell Biology

JF - Journal of Cell Biology

IS - 6

ER -

A balancing act: PHLPP2 fine tunes AKT activity and MYC stability in prostate cancer

Abstract

UN SDGs

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Projects

Targeting MYC driven PC by combining targeted radionuclide therapy with ribosome biogenesis inhibition as a new therapy in CRPC and neuroendocrine PC

Investigating the origins of neuroendocrine prostate cancer

Cite this