A balancing act: PHLPP2 fine tunes AKT activity and MYC stability in prostate cancer

Research output: Contribution to journalEditorialOtherpeer-review

Abstract

PTEN loss stimulates prostate tumor progression by sustaining AKT activation. Nowak et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201902048) surprisingly show that the AKT-suppressing phosphatase PHLPP2 promotes disease progression in the context of dual PTEN and p53 loss by increasing MYC stability.
Original languageEnglish
Pages (from-to)1771-1772
Number of pages2
JournalJournal of Cell Biology
Volume218
Issue number6
DOIs
Publication statusPublished - 3 Jun 2019

Cite this

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title = "A balancing act: PHLPP2 fine tunes AKT activity and MYC stability in prostate cancer",
abstract = "PTEN loss stimulates prostate tumor progression by sustaining AKT activation. Nowak et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201902048) surprisingly show that the AKT-suppressing phosphatase PHLPP2 promotes disease progression in the context of dual PTEN and p53 loss by increasing MYC stability.",
author = "Roxanne Toivanen and Luc Furic",
year = "2019",
month = "6",
day = "3",
doi = "10.1083/jcb.201904119",
language = "English",
volume = "218",
pages = "1771--1772",
journal = "Journal of Cell Biology",
issn = "0021-9525",
publisher = "Rockefeller University Press",
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}

A balancing act : PHLPP2 fine tunes AKT activity and MYC stability in prostate cancer. / Toivanen, Roxanne; Furic, Luc.

In: Journal of Cell Biology, Vol. 218, No. 6, 03.06.2019, p. 1771-1772.

Research output: Contribution to journalEditorialOtherpeer-review

TY - JOUR

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AU - Furic, Luc

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N2 - PTEN loss stimulates prostate tumor progression by sustaining AKT activation. Nowak et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201902048) surprisingly show that the AKT-suppressing phosphatase PHLPP2 promotes disease progression in the context of dual PTEN and p53 loss by increasing MYC stability.

AB - PTEN loss stimulates prostate tumor progression by sustaining AKT activation. Nowak et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201902048) surprisingly show that the AKT-suppressing phosphatase PHLPP2 promotes disease progression in the context of dual PTEN and p53 loss by increasing MYC stability.

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DO - 10.1083/jcb.201904119

M3 - Editorial

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