A 2012 evidence-based algorithm for the pharmacotherapy for obsessive-compulsive disorder

Dan J Stein, Nastassja Koen, Naomi A Fineberg, Leonardo F. Fontenelle, Hisato Matsunaga, David Osser, Helen Blair Simpson

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53 Citations (Scopus)


There is a need to synthesize the growing body of literature on the pharmacotherapeutic management of patients with obsessive-compulsive disorder for clinicians working at a primary care level. We have aimed to generate a simple, easy-to-follow algorithm for the primary care practitioner. This seven-step algorithm addresses diagnosis of obsessive-compulsive disorder, initiation of pharmacotherapy, monitoring and maintenance treatment, and guidelines for the management of patients who are resistant to initial therapy. In creating this algorithm, we have drawn on the body of published evidence, as well as on expert opinion.

Original languageEnglish
Pages (from-to)211-219
Number of pages9
JournalCurrent Psychiatry Reports
Issue number3
Publication statusPublished - Jun 2012
Externally publishedYes


  • Algorithm
  • Anxiety disorders
  • Evidence-based
  • Obsessive-compulsive disorder
  • OCD
  • Pharmacotherapy
  • Primary care
  • Treatment

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