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5 Citations (Scopus)

Activation of Macrophages and Microglia by Interferon-γ and Lipopolysaccharide Increases Methylglyoxal Production: A New Mechanism in the Development of Vascular Complications and Cognitive Decline in Type 2 Diabetes Mellitus?

Dhananjayan, K., Gunawardena, D., Hearn, N. L., Sonntag, T., Moran, C., Gyengesi, E., Srikanth, V. & Münch, G., 2017, In : Journal of Alzheimer's Disease. 59, 2, p. 467-479 13 p.

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23 Citations (Scopus)

Activation of mineralocorticoid receptors by exogenous glucocorticoids and the development of cardiovascular inflammatory responses in adrenalectomized rats

Young, M. J., Morgan, J., Brolin, K., Fuller, P. J. & Funder, J. W., Jun 2010, In : Endocrinology. 151, 6, p. 2622-2628 7 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Activation of mitochondrial fusion provides a new treatment for mitochondria-related diseases

Szabo, A., Sumegi, K., Fekete, K., Hocsak, E., Debreceni, B., Setalo, G., Kovacs, K., Deres, L., Kengyel, A., Kovacs, D., Mandl, J., Nyitrai, M., Febbraio, M. A., Gallyas, F. & Sumegi, B., 1 Apr 2018, In : Biochemical Pharmacology. 150, p. 86-96 11 p.

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10 Citations (Scopus)

Activation of mouse cumulus-oocyte complex maturation in vitro through EGF-like activity of versican

Dunning, K. R., Watson, L. N., Zhang, V. J., Brown, H. M., Kaczmarek, A. K., Robker, R. L. & Russell, D. L., 1 May 2015, In : Biology of Reproduction. 92, 5, 10 p., 116.

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26 Citations (Scopus)

Activation of mu opioid receptors sensitizes Transient Receptor Potential Vanilloid Type 1 (TRPV1) via beta-arrestin-2-mediated cross-talk

Rowan, M. P., Bierbower, S. M., Eskander, M. A., Szteyn, K., Por, E. D., Gomez, R., Veldhuis, N. A., Bunnett, N. W. & Jeske, N. A., 2014, In : PLoS ONE. 9, 4, 12 p., e93688.

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2 Citations (Scopus)

Activation of naïve CD4 + T cells re-tunes STAT1 signaling to deliver unique cytokine responses in memory CD4 + T cells

Twohig, J. P., Cardus Figueras, A., Andrews, R., Wiede, F., Cossins, B. C., Derrac Soria, A., Lewis, M. J., Townsend, M. J., Millrine, D., Li, J., Hill, D. G., Uceda Fernandez, J., Liu, X., Szomolay, B., Pepper, C. J., Taylor, P. R., Pitzalis, C., Tiganis, T., Williams, N. M., Jones, G. W. & 1 others, Jones, S. A., 1 Apr 2019, In : Nature Immunology. 20, 4, p. 458-470 13 p.

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116 Citations (Scopus)

Activation of natural killer (NK) T cells during murine cytomegalovirus infection enhances the antiviral response mediated by NK cells

Van Dommelen, S. L. H., Tabarias, H. A., Smyth, M. J. & Degli-Esposti, M. A., 1 Feb 2003, In : Journal of Virology. 77, 3, p. 1877-1884 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Activation of neurokinin NK2 receptors by tackykinin peptides causes contraction of uterus in pregnant women near term

Patak, E. N., Ziccone, S., Story, M. E., Fleming, A. J., Lilley, A. & Pennefather, J. N., 2000, In : Molecular Human Reproduction. p. 549 - 554 6 p.

Research output: Contribution to journalArticleResearchpeer-review

43 Citations (Scopus)

Activation of New Raman Modes by Inversion Symmetry Breaking in Type II Weyl Semimetal Candidate T′-MoTe2

Chen, S. Y., Goldstein, T., Venkataraman, D., Ramasubramaniam, A. & Yan, J., 14 Sep 2016, In : Nano Letters. 16, 9, p. 5852-5860 9 p.

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17 Citations (Scopus)

Activation of NF-kappaB transcription factor in the preterm ovine brain and placenta after acute LPS exposure

Briscoe, T., Duncan, J., Cock, M. L., Choo, J., Rice, G. E., Harding, R., Scheerlinck, J-P. Y. & Rees, S. M., 2006, In : Journal of Neuroscience Research. 83, 4, p. 567 - 574 8 p.

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77 Citations (Scopus)

Activation of NK cells by ADCC antibodies and HIV disease progression

Chung, A. W., Navis, M., Isitman, G., Silvers, J., Amin, J., Kent, S. J. & Stratov, I., 1 Oct 2011, In : JAIDS. 58, 2, p. 127-131 5 p.

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14 Citations (Scopus)

Activation of NK cells by HIV-specific ADCC antibodies: Role for granulocytes in expressing HIV-1 peptide epitopes

Madhavi, V., Navis, M., Chung, A. W., Isitman, G., Wren, L. H., De Rose, R., Kent, S. J. & Stratov, I., May 2013, In : Human Vaccines & Immunotherapeutics. 9, 5, p. 1011-1018 8 p.

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131 Citations (Scopus)

Activation of palm shells by phosphoric acid impregnation for high yielding activated carbon

Lim, W. C., Srinivasakannan, C. & Balasubramanian, N., 2010, In : Journal of Analytical and Applied Pyrolysis. 88, 2, p. 181 - 186 6 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Activation of peripheral blood mononuclear cells and extracellular matrix and inflammatory gene profile in acute myocardial infarction

Fang, L., Du, X. J., Gao, X. M. & Dart, A. M., Aug 2010, In : Clinical Science. 119, 4, p. 175-183 9 p.

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70 Citations (Scopus)

Activation of photocatalytic water oxidation on N-doped ZnO bundle-like nanoparticles under visible light

Zong, X., Sun, C., Yu, H., Chen, Z., Xing, Z., Ye, D., Lu, G. Q. M., Li, X. & Wang, L., 2013, In : Journal of Physical Chemistry C. 117, 10, p. 4937 - 4942 6 p.

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90 Citations (Scopus)

Activation of PPARa ameliorates hepatic insulin resistance and steatosis in high fructose-fed mice despite increased endoplasmic reticulum stress

Chan, S. M. H., Sun, R-Q., Zeng, X-Y., Choong, Z-H., Wang, H., Watt, M. J. & Ye, J-M., 2013, In : Diabetes. 62, 6, p. 2095 - 2105 11 p.

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26 Citations (Scopus)

Activation of protease-activated receptor-2 leads to inhibition of osteoclast differentiation

Smith, R. A., Ransjo, M., Tatarczuch, L., Song, S-J., Pagel, C. N., Morrison, J. R., Pike, R. N. & Mackie, E. J., 2004, In : Journal of Bone and Mineral Research. 19, 3, p. 507 - 516 10 p.

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153 Citations (Scopus)

Activation of protease-activated receptors by gingipains from Porphyromonas gingivalis leads to platelet aggregation: A new trait in microbial pathogenicity

Lourbakos, A., Yuan, Y. P., Jenkins, A. L., Travis, J., Andrade-Gordon, P., Santulli, R., Potempa, J. & Pike, R. N., 15 Jun 2001, In : Blood. 97, 12, p. 3790-3797 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Activation of protease-activated receptors by gingipains from porphyromonas gingivalis leads to platelet aggregation: a new trait in micobial pathogenicity

Lourbakos, A., Yuan, Y., Jenkins, A. L., Travis, J., Andrade-Gordon, P., Santulli, R., Potempa, J. & Pike, R. N., 2001, In : Blood. 97, 12, p. 3790 - 3797 8 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Activation of protein phosphatase 2A in FLT3+ acute myeloid leukemia cells enhances the cytotoxicity of FLT3 tyrosine kinase inhibitors

Smith, A. M., Dun, M. D., Lee, E. M., Harrison, C., Kahl, R., Flanagan, H., Panicker, N., Mashkani, B., Don, A. S., Morris, J., Toop, H., Lock, R. B., Powell, J. A., Thomas, D., Guthridge, M. A., Moore, A., Ashman, L. K., Skelding, K. A., Enjeti, A. & Verrills, N. M., 2016, In : Oncotarget. 7, 30, p. 47465-47478 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Activation of pruritogenic TGR5, MRGPRA3, and MRGPRC11 on colon-innervating afferents induces visceral hypersensitivity

Castro, J., Harrington, A. M., Lieu, T., Garcia-Caraballo, S., Maddern, J., Schober, G., O’Donnell, T., Grundy, L., Lumsden, A. L., Miller, P., Ghetti, A., Steinhoff, M. S., Poole, D. P., Dong, X., Chang, L., Bunnett, N. & Brierley, S. M., 19 Sep 2019, In : JCI Insight. 4, 18, 42 p.

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45 Citations (Scopus)

Activation of S6K1 (p70 ribosomal protein S6 kinase 1) requires an initial calcium-dependent priming event involving formation of a high-molecular-mass signalling complex

Hannan, K. M., Thomas, G. & Pearson, R. B., 1 Mar 2003, In : Biochemical Journal. 370, 2, p. 469-477 9 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Activation of Serine One-Carbon Metabolism by Calcineurin Aβ1 Reduces Myocardial Hypertrophy and Improves Ventricular Function

Padrón-Barthe, L., Villalba-Orero, M., Gómez-Salinero, J. M., Acín-Pérez, R., Cogliati, S., López-Olañeta, M., Ortiz-Sánchez, P., Bonzón-Kulichenko, E., Vázquez, J., García-Pavía, P., Rosenthal, N., Enríquez, J. A. & Lara-Pezzi, E., 13 Feb 2018, In : Journal of the American College of Cardiology. 71, 6, p. 654-667 14 p.

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168 Citations (Scopus)

Activation of soluble guanylate cyclase reverses experimental pulmonary hypertension and vascular remodeling

Dumitrascu, R., Weissmann, N., Ghofrani, H. A., Dony, E., Beurerlein, K., Schmidt, H., Stasch, J-P., Gnoth, M. J., Seeger, W., Grimminger, F. & Schermuly, R. T., 2006, In : Circulation. 113, 2, p. 286 - 295 10 p.

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28 Citations (Scopus)

Activation of spinally projecting and nitrergic neurons in the PVN following heat exposure

Cham, J. L., Klein, R., Owens, N. C., Mathai, M., McKinley, M. J. & Badoer, E., 2006, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 291, p. 91 - 101 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Activation of Src family tyrosine kinases by ferric ions

Baldwin, G. S., Lio, D. S. S., Ferrand, A., Catimel, B., Shehan, B. P., Norton, R. S. & Cheng, H. C., Mar 2014, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1844, 3, p. 487-496 10 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Activation of Src induces mitochondrial localisation of de2-7EGFR (EGFRvIII) in glioma cells: Implications for glucose metabolism

Cvrljevic, A., Akhavan, D., Wu, M., Martinello, P., Furnari, F., Johnston, A., Guo, D., Pike, L., Cavenee, W., Scott, A., Mischel, P., Hoogenraad, N. & Johns, T., 2011, In : Journal of Cell Science. 124, Pt 17, p. 2938 - 2950 13 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Activation of SRC kinase and phosphorylation of signal transducer and activator of transcription-5 are required for decidual transformation of human endometrial stromal cells

Nagashima, T., Maruyama, T., Uchida, H., Kajitani, T., Arase, T., Ono, M., Oda, H., Kagami, M., Masuda, H., Nishikawa-Uchida, S., Asada, H. & Yoshimura, Y., 2008, In : Endocrinology. 149, 3, p. 1227 - 1234 8 p.

Research output: Contribution to journalArticleResearchpeer-review

59 Citations (Scopus)

Activation of Synovial Cell p38 MAP Kinase by Macrophage Migration Inhibitory Factor

Santos, L. L., Lacey, D., Yang, Y. H., Leech, M. T. & Morand, E. F., 2004, In : The Journal of Rheumatology. 31, 6, p. 1038 - 1043 6 p.

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

Activation of the 43 kDa inositol polyphosphate 5-phosphatase by 14-3- 3ζ

Campbell, J. K., Gurung, R., Romero, S., Speed, C. J., Andrews, R. K., Berndt, M. C. & Mitchell, C. A., 1997, In : Biochemistry. 36, 49, p. 15363-15370 8 p.

Research output: Contribution to journalArticleResearchpeer-review

121 Citations (Scopus)

Activation of the canonical wingless/T-cell factor signaling pathway promotes invasive differentiation of human trophoblast

Pollheimer, J., Loregger, T., Sonderegger, S. E., Saleh, L., Bauer, S., Bilban, M., Czerwenka, K., Husslein, P. & Knofler, M., 2006, In : American Journal of Pathology. 168, 4, p. 1134 - 1147 14 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Activation of the c-myc oncogene in B and T lymphoid tumors.

Cory, S., Gerondakis, S., Corcoran, L. M., Bernard, O., Webb, E. & Adams, J. M., 1 Jan 1984, In : Current topics in microbiology and immunology. 113, p. 161-165 5 p.

Research output: Contribution to journalArticleResearchpeer-review

78 Citations (Scopus)

Activation of the ERK pathway precedes tubular proliferation in the obstructed rat kidney

Masaki, T., Foti, R., Hill, P. A., Ikezumi, Y., Atkins, R. C. & Nikolic-Paterson, D. J., 2003, In : Kidney International. 63, 4, p. 1256 - 1264 9 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Activation of the erythroid K-Cl cotransporter Kcc1 enhances sickle cell disease pathology in a humanized mouse model

Brown, F. C., Conway, A. J., Cerruti, L., Collinge, J. E., McLean, C., Wiley, J. S., Kile, B. T., Jane, S. M. & Curtis, D. J., 2015, In : Blood. 126, 26, p. 2863-2870 8 p.

Research output: Contribution to journalArticleResearchpeer-review

54 Citations (Scopus)

Activation of the extracellular-signal regulated protein kinase pathway in human glomerulopathies

Masaki, T., Stambe, C., Hill, P. A., Dowling, J. P., Atkins, R. C. & Nikolic-Paterson, D. J., 2004, In : Journal of the American Society of Nephrology. 15, 7, p. 1835 - 1843 9 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)

Activation of the hypothalamo-pituitary-adrenal axis by isolation and restraint stress during lactation in ewes: effect of the presence of the lamb and suckling

Tilbrook, A. J., Turner, A. I., Ibbott, M. D. & Clarke, I. J., 2006, In : Endocrinology. 147, 7, p. 3501 - 3509 9 p.

Research output: Contribution to journalArticleResearchpeer-review

1167 Citations (Scopus)

Activation of the interferon system by short-interfering RNAs

Sledz, C. A., Holko, M., de Veer, M. J., Silverman, R. H. & Williams, B. R. G., 2003, In : Nature Cell Biology. 5, 9, p. 834 - 839 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Activation of the Kallikrein Kinnin system in interstitial cystitis

Rosamilia, A., Clements, J., Dwyer, P. L., Kende, M. & Campbell, D. J., 1999, In : Journal of Urology. p. 129 - 134 6 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

Activation of the kynurenine pathway and increased production of the excitotoxin quinolinic acid following traumatic brain injury in humans

Yan, E. B., Frugier, T. J., Lim, C. K., Heng, B., Sundaram, G., Tan, M., Rosenfeld, J. V., Walker, D. W., Guillemin, G. J. & Morganti-Kossmann, M. C., 12 Dec 2015, In : Journal of Neuroinflammation. 12, 1, 17 p., 110.

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8 Citations (Scopus)

Activation of the lectin pathway of complement in experimental human keratitis with Pseudomonas aeruginosa

Osthoff, M., Brown, K. D., Kong, D. C. M., Daniell, M. & Eisen, D. P., 2014, In : Molecular Vision. 20, p. 38 - 45 8 p.

Research output: Contribution to journalArticleResearchpeer-review

62 Citations (Scopus)

Activation of the Lymphotoxin β Receptor by Cross-Linking Induces Chemokine Production and Growth Arrest in A375 Melanoma Cells

Degli-Esposti, M. A., Davis-Smith, T., Din, W. S., Smolak, P. J., Goodwin, R. G. & Smith, C. A., 15 Feb 1997, In : Journal of Immunology. 158, 4, p. 1756-1762 7 p.

Research output: Contribution to journalArticleResearchpeer-review

256 Citations (Scopus)

Activation of the mammalian immune system by siRNAs

Marques, J. T. & Williams, B. R. G., 2005, In : Nature Biotechnology. 23, 11, p. 1399 - 1405 7 p.

Research output: Contribution to journalArticleResearchpeer-review

67 Citations (Scopus)

Activation of the mitogen-activated protein kinase pathway induces transcription of the PAC-1 phosphatase gene

Grumont, R. J., Rasko, J. E. J., Strasser, A. & Gerondakis, S., 1 Jan 1996, In : Molecular and Cellular Biology. 16, 6, p. 2913-2921 9 p.

Research output: Contribution to journalArticleResearchpeer-review

97 Citations (Scopus)

Activation of the NLRP3 inflammasome by IAV virulence protein PB1-F2 contributes to severe pathophysiology and disease

McAuley, J., Tate, M., Mackenzie-kludas, C., Pinar, A., Zeng, W., Stutz, A., Latz, E., Brown, L. E. & Mansell, A. S., 2013, In : PLoS Pathogens. 9, 5 (art. no. e1003392 ), p. 1 - 14 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
706 Citations (Scopus)

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1beta in type 2 diabetes

Masters, S. L., Dunne, A., Subramanian, S. L., Hull, R. L., Tannahill, G. M., Sharp, F. A., Becker, C., Franchi, L., Yoshihara, E., Chen, Z., Mullooly, N., Mielke, L. A., Harris, J., Coll, R. C., Mills, K. H. G., Mok, K. H., Newsholme, P., Nunez, G., Yodoi, J., Kahn, S. E. & 2 others, Lavelle, E. C. & O'Neill, L. A. J., 2010, In : Nature Immunology. 11, 10, p. 897 - 904 8 p.

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)

Activation of the P2Z/P2X7 receptor in human lymphocytes produces a delayed permeability lesion: Involvement of phospholipase D

Fernando, K. C., Gargett, C. E. & Wiley, J. S., 15 Feb 1999, In : Archives of Biochemistry and Biophysics. 362, 2, p. 197-202 6 p.

Research output: Contribution to journalArticleResearchpeer-review

198 Citations (Scopus)

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

Hildebrand, J. M., Tanzer, M. C., Lucet, I. S., Young, S. N., Spall, S. K., Sharma, P., Pierotti, C., Garnier, J-M., Dobson, R. C. J., Webb, A. I., Tripaydonis, A., Babon, J. J., Mulcair, M., Scanlon, M. J., Alexander, W. S., Wilks, A. F., Czabotar, P. E., Lessene, G., Murphy, J. M. & Silke, J., 2014, In : Proceedings of the National Academy of Sciences. 111, 42, p. 15072 - 15077 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
82 Citations (Scopus)

Activation of the Ras/mitogen-activated protein kinase pathway by kinase-defective epidermal growth factor receptors results in cell survival but not proliferation

Walker, F., Kato, A., Gonez, L. J., Hibbs, M. L., Pouliot, N., Levitzki, A. & Burgess, A. W., 1 Jan 1998, In : Molecular and Cellular Biology. 18, 12, p. 7192-7204 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
182 Citations (Scopus)

Activation of the Ras signalling pathway in human breast cancer cells overexpressing erbB-2

Janes, P. W., Daly, R. J., DeFazio, A. & Sutherland, R. L., 1 Dec 1994, In : Oncogene. 9, 12, p. 3601-3608 8 p.

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)

Activation of the renin-angiotensin system mediates the effects of dietary salt intake on atherogenesis in the apolipoprotein E knockout mouse

Tikellis, C., Pickering, R. J., Tsorotes, D., Huet, O., Chin-Dusting, J., Cooper, M. E. & Thomas, M. C., Jul 2012, In : Hypertension. 60, 1, p. 98-105 8 p.

Research output: Contribution to journalArticleResearchpeer-review