46, xx Disorders of Sex Development

Garry L. Warne, Jacqueline K. Hewitt

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Abstract

46, XX DSD comprise the most common group of genital abnormalities, with congenital adrenal hyperplasia (CAH) being the most important, not only because of its frequency but also because of its life-threatening complications without treatment. The different disorders are described, showing the range of genetic and enzymatic anomalies that lead to excess androgen production causing abnormal virilisation of a female foetus. The non-hormonal anatomical defects of genital development are also mentioned.

Original languageEnglish
Title of host publicationDisorders of Sex Development: An Integrated Approach to Management
PublisherSpringer
Pages53-61
Number of pages9
ISBN (Electronic)9783642229640
ISBN (Print)9783642229633
DOIs
Publication statusPublished - 1 Jan 2012
Externally publishedYes

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