3He diffusion MRI of the lung

Mark S Conradi; Dmitriy A Yablonskiy; Woods C Jason; David S Gierada; Richard E Jacob; Yulin V Chang; Cliff Khuat Chye Choong; Alex L Sukstanskii; Tariq Tanoli; Stephen S Lefrak; Joel Cooper

doi:10.1016/j.acra.2005.07.006

3He diffusion MRI of the lung

Mark S Conradi, Dmitriy A Yablonskiy, Woods C Jason, David S Gierada, Richard E Jacob, Yulin V Chang, Cliff Khuat Chye Choong, Alex L Sukstanskii, Tariq Tanoli, Stephen S Lefrak, Joel Cooper

Surgery Monash Health

Research output: Contribution to journal › Article › Research › peer-review

33 Citations (Scopus)

Abstract

Rationale and Objectivesa?? MR imaging of the restricted diffusion of laser-polarized 3He gas provides unique insights into the changes in lung microstructure in emphysema. Resultsa?? We discuss measurements of ventilation (spin density), mean diffusivity, and the anisotropy of diffusion, which yields the mean acinar airway radius. In addition, the use of spatially modulated longitudinal magnetization allows diffusion to be measured over longer distances and times, with sensitivity to collateral ventilation paths. Early results are also presented for spin density and diffusivity maps made with a perfluorinated inert gas, C3F8. Methodsa?? Techniques for purging and imaging excised lungs are discussed

Original language	English
Pages (from-to)	1406 - 1413
Number of pages	8
Journal	Academic Radiology
Volume	12
Issue number	11
DOIs	https://doi.org/10.1016/j.acra.2005.07.006
Publication status	Published - 2005

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10.1016/j.acra.2005.07.006

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@article{d2339463439e46358b610f5fe7c4515a,

title = "3He diffusion MRI of the lung",

abstract = "Rationale and Objectivesa?? MR imaging of the restricted diffusion of laser-polarized 3He gas provides unique insights into the changes in lung microstructure in emphysema. Resultsa?? We discuss measurements of ventilation (spin density), mean diffusivity, and the anisotropy of diffusion, which yields the mean acinar airway radius. In addition, the use of spatially modulated longitudinal magnetization allows diffusion to be measured over longer distances and times, with sensitivity to collateral ventilation paths. Early results are also presented for spin density and diffusivity maps made with a perfluorinated inert gas, C3F8. Methodsa?? Techniques for purging and imaging excised lungs are discussed",

author = "Conradi, {Mark S} and Yablonskiy, {Dmitriy A} and Jason, {Woods C} and Gierada, {David S} and Jacob, {Richard E} and Chang, {Yulin V} and Choong, {Cliff Khuat Chye} and Sukstanskii, {Alex L} and Tariq Tanoli and Lefrak, {Stephen S} and Joel Cooper",

year = "2005",

doi = "10.1016/j.acra.2005.07.006",

language = "English",

volume = "12",

pages = "1406 -- 1413",

journal = "Academic Radiology",

issn = "1076-6332",

publisher = "Elsevier BV",

number = "11",

}

3He diffusion MRI of the lung. / Conradi, Mark S; Yablonskiy, Dmitriy A; Jason, Woods C; Gierada, David S; Jacob, Richard E; Chang, Yulin V; Choong, Cliff Khuat Chye; Sukstanskii, Alex L; Tanoli, Tariq; Lefrak, Stephen S; Cooper, Joel.

In: Academic Radiology, Vol. 12, No. 11, 2005, p. 1406 - 1413.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - 3He diffusion MRI of the lung

AU - Conradi, Mark S

AU - Yablonskiy, Dmitriy A

AU - Jason, Woods C

AU - Gierada, David S

AU - Jacob, Richard E

AU - Chang, Yulin V

AU - Choong, Cliff Khuat Chye

AU - Sukstanskii, Alex L

AU - Tanoli, Tariq

AU - Lefrak, Stephen S

AU - Cooper, Joel

PY - 2005

Y1 - 2005

N2 - Rationale and Objectivesa?? MR imaging of the restricted diffusion of laser-polarized 3He gas provides unique insights into the changes in lung microstructure in emphysema. Resultsa?? We discuss measurements of ventilation (spin density), mean diffusivity, and the anisotropy of diffusion, which yields the mean acinar airway radius. In addition, the use of spatially modulated longitudinal magnetization allows diffusion to be measured over longer distances and times, with sensitivity to collateral ventilation paths. Early results are also presented for spin density and diffusivity maps made with a perfluorinated inert gas, C3F8. Methodsa?? Techniques for purging and imaging excised lungs are discussed

AB - Rationale and Objectivesa?? MR imaging of the restricted diffusion of laser-polarized 3He gas provides unique insights into the changes in lung microstructure in emphysema. Resultsa?? We discuss measurements of ventilation (spin density), mean diffusivity, and the anisotropy of diffusion, which yields the mean acinar airway radius. In addition, the use of spatially modulated longitudinal magnetization allows diffusion to be measured over longer distances and times, with sensitivity to collateral ventilation paths. Early results are also presented for spin density and diffusivity maps made with a perfluorinated inert gas, C3F8. Methodsa?? Techniques for purging and imaging excised lungs are discussed

UR - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2140257/pdf/nihms29225.pdf

U2 - 10.1016/j.acra.2005.07.006

DO - 10.1016/j.acra.2005.07.006

M3 - Article

VL - 12

SP - 1406

EP - 1413

JO - Academic Radiology

JF - Academic Radiology

SN - 1076-6332

IS - 11

ER -

3He diffusion MRI of the lung

Abstract

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