3D Models for Ovarian Cancer

Verena Kast, Daniela Loessner

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

5 Citations (Scopus)

Abstract

The main reasons for the slow progress in improving survival outcomes for ovarian cancer are the ‘one-size-fits-all’ therapy and lack of clinically relevant experimental models that represent the advanced stages of the human disease. The interaction of tumour cells with their surrounding niche, the tumour microenvironment, influences the spread of ovarian cancer cells within the peritoneum and their responses to therapeutics. Scientists are increasingly using 3D cell culture models to dissect the role of the tumour microenvironment in cancer development and progression and the treatment of this disease. In this chapter, we will briefly describe the tumour microenvironment of ovarian cancer. Then, we will review some of the clinically relevant experimental approaches, such as spheroid, organoid and organotypic models, that have been developed for the 3D culture of ovarian cancer cells using different tools, including hydrogels, scaffolds and cancer-on-a-chip devices, to mimic selected components of the tumour microenvironment.

Original languageEnglish
Title of host publicationOvarian Cancer
Subtitle of host publicationMolecular & Diagnostic Imaging and Treatment Strategies
EditorsHeide Schatten
Place of PublicationCham Switzerland
PublisherSpringer
Chapter9
Pages139-149
Number of pages11
Edition1st
ISBN (Electronic)9783030733599
ISBN (Print)9783030733582
DOIs
Publication statusPublished - 2021

Publication series

NameAdvances in Experimental Medicine and Biology
PublisherSpringer Nature Switzerland
Volume1330
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • 3D cell culture
  • Cancer-on-a-chip
  • Hydrogels
  • Organoids
  • Organotypic cultures
  • Scaffolds
  • Spheroids
  • Tumour microenvironment

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