3d breast tumor models for radiobiology applications

Akhilandeshwari Ravichandran; Julien Clegg; Mark N. Adams; Madison Hampson; Andrew Fielding; Laura J. Bray

doi:10.3390/cancers13225714

3d breast tumor models for radiobiology applications

Akhilandeshwari Ravichandran, Julien Clegg, Mark N. Adams, Madison Hampson, Andrew Fielding, Laura J. Bray

Research output: Contribution to journal › Review Article › Research › peer-review

5 Citations (Scopus)

Abstract

Breast cancer is a leading cause of cancer‐associated death in women. The clinical management of breast cancers is normally carried out using a combination of chemotherapy, surgery and radiation therapy. The majority of research investigating breast cancer therapy until now has mainly utilized two‐dimensional (2D) in vitro cultures or murine models of disease. However, there has been significant uptake of three‐dimensional (3D) in vitro models by cancer researchers over the past decade, highlighting a complimentary model for studies of radiotherapy, especially in conjunction with chemotherapy. In this review, we underline the effects of radiation therapy on normal and malignant breast cells and tissues, and explore the emerging opportunities that pre‐clinical 3D models offer in improving our understanding of this treatment modality.

Original language	English
Article number	5714
Number of pages	20
Journal	Cancers
Volume	13
Issue number	22
DOIs	https://doi.org/10.3390/cancers13225714
Publication status	Published - 15 Nov 2021
Externally published	Yes

Keywords

3D radiobiology
In vitro breast cancer models
Radiation therapy
Radiosensitizers

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/cancers13225714

Cite this

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title = "3d breast tumor models for radiobiology applications",

abstract = "Breast cancer is a leading cause of cancer‐associated death in women. The clinical management of breast cancers is normally carried out using a combination of chemotherapy, surgery and radiation therapy. The majority of research investigating breast cancer therapy until now has mainly utilized two‐dimensional (2D) in vitro cultures or murine models of disease. However, there has been significant uptake of three‐dimensional (3D) in vitro models by cancer researchers over the past decade, highlighting a complimentary model for studies of radiotherapy, especially in conjunction with chemotherapy. In this review, we underline the effects of radiation therapy on normal and malignant breast cells and tissues, and explore the emerging opportunities that pre‐clinical 3D models offer in improving our understanding of this treatment modality.",

keywords = "3D radiobiology, In vitro breast cancer models, Radiation therapy, Radiosensitizers",

author = "Akhilandeshwari Ravichandran and Julien Clegg and Adams, {Mark N.} and Madison Hampson and Andrew Fielding and Bray, {Laura J.}",

note = "Funding Information: Funding: This research was funded by the National Breast Cancer Foundation through PF‐16‐ 004. L.J.B. acknowledges the support of grant 1159637 awarded through the 2018 Priority‐ driven Collaborative Cancer Research Scheme and co‐funded by Cancer Australia and the Leukaemia Foundation of Australia. L.J.B. also acknowledges the Australian Research Council for funding of the ARC Industrial Transformation Training Centre for Cell and Tissue Engineering Technologies (IC190100026). Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = nov,

day = "15",

doi = "10.3390/cancers13225714",

language = "English",

volume = "13",

journal = "Cancers",

issn = "2072-6694",

publisher = "MDPI AG",

number = "22",

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TY - JOUR

T1 - 3d breast tumor models for radiobiology applications

AU - Ravichandran, Akhilandeshwari

AU - Clegg, Julien

AU - Adams, Mark N.

AU - Hampson, Madison

AU - Fielding, Andrew

AU - Bray, Laura J.

N1 - Funding Information: Funding: This research was funded by the National Breast Cancer Foundation through PF‐16‐ 004. L.J.B. acknowledges the support of grant 1159637 awarded through the 2018 Priority‐ driven Collaborative Cancer Research Scheme and co‐funded by Cancer Australia and the Leukaemia Foundation of Australia. L.J.B. also acknowledges the Australian Research Council for funding of the ARC Industrial Transformation Training Centre for Cell and Tissue Engineering Technologies (IC190100026). Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2021/11/15

Y1 - 2021/11/15

N2 - Breast cancer is a leading cause of cancer‐associated death in women. The clinical management of breast cancers is normally carried out using a combination of chemotherapy, surgery and radiation therapy. The majority of research investigating breast cancer therapy until now has mainly utilized two‐dimensional (2D) in vitro cultures or murine models of disease. However, there has been significant uptake of three‐dimensional (3D) in vitro models by cancer researchers over the past decade, highlighting a complimentary model for studies of radiotherapy, especially in conjunction with chemotherapy. In this review, we underline the effects of radiation therapy on normal and malignant breast cells and tissues, and explore the emerging opportunities that pre‐clinical 3D models offer in improving our understanding of this treatment modality.

AB - Breast cancer is a leading cause of cancer‐associated death in women. The clinical management of breast cancers is normally carried out using a combination of chemotherapy, surgery and radiation therapy. The majority of research investigating breast cancer therapy until now has mainly utilized two‐dimensional (2D) in vitro cultures or murine models of disease. However, there has been significant uptake of three‐dimensional (3D) in vitro models by cancer researchers over the past decade, highlighting a complimentary model for studies of radiotherapy, especially in conjunction with chemotherapy. In this review, we underline the effects of radiation therapy on normal and malignant breast cells and tissues, and explore the emerging opportunities that pre‐clinical 3D models offer in improving our understanding of this treatment modality.

KW - 3D radiobiology

KW - In vitro breast cancer models

KW - Radiation therapy

KW - Radiosensitizers

UR - http://www.scopus.com/inward/record.url?scp=85118947086&partnerID=8YFLogxK

U2 - 10.3390/cancers13225714

DO - 10.3390/cancers13225714

M3 - Review Article

C2 - 34830869

AN - SCOPUS:85118947086

SN - 2072-6694

VL - 13

JO - Cancers

JF - Cancers

IS - 22

M1 - 5714

ER -

3d breast tumor models for radiobiology applications

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

ARC Training Centre for Cell and Tissue Engineering Technologies

Cite this

3d breast tumor models for radiobiology applications

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Projects

ARC Training Centre for Cell and Tissue Engineering Technologies

Cite this