2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy

Jingmei Li; Linda S. Lindström; Jia Nee Foo; Sajjad Rafiq; Marjanka K. Schmidt; Paul D P Pharoah; Kyriaki Michailidou; Joe Dennis; Manjeet K. Bolla; Qin Wang; Laura J. Van't Veer; Sten Cornelissen; Emiel J. Rutgers; Melissa C. Southey; Carmel Apicella; Gillian S Dite; John L. Hopper; Peter A. Fasching; Lothar Haeberle; Arif B Ekici; Matthias W. Beckmann; Carl Blomqvist; Taru A. Muranen; Kristiina Aittomäki; Annika Lindblom; Sara Margolin; Arto Mannermaa; Veli-Matti Kosma; Jaana M. Hartikainen; Vesa Kataja; Georgia Chenevix-Trench; Kelly-Anne Phillips; Sue-Anne McLachlan; Diether Lambrechts; Bernard Thienpont; Ann Smeets; Hans Wildiers; Jenny Chang-Claude; Dieter Flesch-Janys; Petra Seibold; Anja Rudolph; Graham G. Giles; Laura Baglietto; Gianluca Severi; Christopher A Haiman; Brian E Henderson; Fredrick Schumacher; Loic Le Marchand; Vessela Kristensen; Grethe I.Grenaker Alnæs; Anne-Lise Borresen-Dale; Silje Nord; Robert Winqvist; Katri Pylkäs; Arja Jukkola-Vuorinen; Mervi Grip; Irene L Andrulis; Julia A Knight; Gord Glendon; Sandrine Tchatchou; Peter Devilee; Robert A.E.M. Tollenaar; Caroline Seynaeve; Maartje J Hooning; Mieke Kriege; Antoinette Hollestelle; Ans M W van den Ouweland; Yi Li; Ute Hamann; Diana Torres; Hans Ulrich Ulmer; Thomas Rüdiger; Chen-Yang Shen; Chia-Ni Hsiung; Pei-Ei Wu; Shou-Tung Chen; Soo-Hwang Teo; Nur Aishah Mohd Taib; Cheng Har Yip; Gwo Fuang Ho; Keitaro Matsuo; Hidemi Ito; Hiroji Iwata; Kazuo Tajima; Daehee Kang; Ji Yeob Choi; Sue K. Park; Keun-Young Yoo; Tom Maishman; William J Tapper; Alison M Dunning; Mitul Shah; Robert Luben; Judith Brown; Chiea Chuen Khor; Diana M Eccles; Heli Nevanlinna; Douglas F Easton; Keith Humphreys; Jianjun Liu; Per Hall; Kamila Czene; kConFab Investigators

doi:10.1038/ncomms5051

2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy

Jingmei Li, Linda S. Lindström, Jia Nee Foo, Sajjad Rafiq, Marjanka K. Schmidt, Paul D P Pharoah, Kyriaki Michailidou, Joe Dennis, Manjeet K. Bolla, Qin Wang, Laura J. Van't Veer, Sten Cornelissen, Emiel J. Rutgers, Melissa C. Southey, Carmel Apicella, Gillian S Dite, John L. Hopper, Peter A. Fasching, Lothar Haeberle, Arif B EkiciMatthias W. Beckmann, Carl Blomqvist, Taru A. Muranen, Kristiina Aittomäki, Annika Lindblom, Sara Margolin, Arto Mannermaa, Veli-Matti Kosma, Jaana M. Hartikainen, Vesa Kataja, Georgia Chenevix-Trench, Kelly-Anne Phillips, Sue-Anne McLachlan, Diether Lambrechts, Bernard Thienpont, Ann Smeets, Hans Wildiers, Jenny Chang-Claude, Dieter Flesch-Janys, Petra Seibold, Anja Rudolph, Graham G. Giles, Laura Baglietto, Gianluca Severi, Christopher A Haiman, Brian E Henderson, Fredrick Schumacher, Loic Le Marchand, Vessela Kristensen, Grethe I.Grenaker Alnæs, Anne-Lise Borresen-Dale, Silje Nord, Robert Winqvist, Katri Pylkäs, Arja Jukkola-Vuorinen, Mervi Grip, Irene L Andrulis, Julia A Knight, Gord Glendon, Sandrine Tchatchou, Peter Devilee, Robert A.E.M. Tollenaar, Caroline Seynaeve, Maartje J Hooning, Mieke Kriege, Antoinette Hollestelle, Ans M W van den Ouweland, Yi Li, Ute Hamann, Diana Torres, Hans Ulrich Ulmer, Thomas Rüdiger, Chen-Yang Shen, Chia-Ni Hsiung, Pei-Ei Wu, Shou-Tung Chen, Soo-Hwang Teo, Nur Aishah Mohd Taib, Cheng Har Yip, Gwo Fuang Ho, Keitaro Matsuo, Hidemi Ito, Hiroji Iwata, Kazuo Tajima, Daehee Kang, Ji Yeob Choi, Sue K. Park, Keun-Young Yoo, Tom Maishman, William J Tapper, Alison M Dunning, Mitul Shah, Robert Luben, Judith Brown, Chiea Chuen Khor, Diana M Eccles, Heli Nevanlinna, Douglas F Easton, Keith Humphreys, Jianjun Liu, Per Hall, Kamila Czene, kConFab Investigators

Research output: Contribution to journal › Article › Research › peer-review

16 Citations (Scopus)

Abstract

Large population-based registry studies have shown that breast cancer prognosis is inherited. Here we analyse single-nucleotide polymorphisms (SNPs) of genes implicated in human immunology and inflammation as candidates for prognostic markers of breast cancer survival involving 1,804 oestrogen receptor (ER)-negative patients treated with chemotherapy (279 events) from 14 European studies in a prior large-scale genotyping experiment, which is part of the Collaborative Oncological Gene-environment Study (COGS) initiative. We carry out replication using Asian COGS samples (n=522, 53 events) and the Prospective Study of Outcomes in Sporadic versus Hereditary breast cancer (POSH) study (n=315, 108 events). Rs4458204-A near CCL20 (2q36.3) is found to be associated with breast cancer-specific death at a genome-wide significant level (n=2,641, 440 events, combined allelic hazard ratio (HR)=1.81 (1.49-2.19); P for trend=1.90 × 10 â ̂'9). Such survival-associated variants can represent ideal targets for tailored therapeutics, and may also enhance our current prognostic prediction capabilities.

Original language	English
Article number	4051
Number of pages	9
Journal	Nature Communications
Volume	5
DOIs	https://doi.org/10.1038/ncomms5051
Publication status	Published - 17 Jun 2014
Externally published	Yes

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SDG 3 Good Health and Well-being

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Li, J., Lindström, L. S., Foo, J. N., Rafiq, S., Schmidt, M. K., Pharoah, P. D. P., Michailidou, K., Dennis, J., Bolla, M. K., Wang, Q., Van't Veer, L. J., Cornelissen, S., Rutgers, E. J., Southey, M. C., Apicella, C., Dite, G. S., Hopper, J. L., Fasching, P. A., Haeberle, L., ... kConFab Investigators (2014). 2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy. Nature Communications, 5, Article 4051. https://doi.org/10.1038/ncomms5051

@article{5ff2390fe12e4b25a743c5c8754c6373,

title = "2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy",

abstract = "Large population-based registry studies have shown that breast cancer prognosis is inherited. Here we analyse single-nucleotide polymorphisms (SNPs) of genes implicated in human immunology and inflammation as candidates for prognostic markers of breast cancer survival involving 1,804 oestrogen receptor (ER)-negative patients treated with chemotherapy (279 events) from 14 European studies in a prior large-scale genotyping experiment, which is part of the Collaborative Oncological Gene-environment Study (COGS) initiative. We carry out replication using Asian COGS samples (n=522, 53 events) and the Prospective Study of Outcomes in Sporadic versus Hereditary breast cancer (POSH) study (n=315, 108 events). Rs4458204-A near CCL20 (2q36.3) is found to be associated with breast cancer-specific death at a genome-wide significant level (n=2,641, 440 events, combined allelic hazard ratio (HR)=1.81 (1.49-2.19); P for trend=1.90 × 10 {\^a}{\^ }'9). Such survival-associated variants can represent ideal targets for tailored therapeutics, and may also enhance our current prognostic prediction capabilities.",

author = "Jingmei Li and Lindstr{\"o}m, \{Linda S.\} and Foo, \{Jia Nee\} and Sajjad Rafiq and Schmidt, \{Marjanka K.\} and Pharoah, \{Paul D P\} and Kyriaki Michailidou and Joe Dennis and Bolla, \{Manjeet K.\} and Qin Wang and \{Van't Veer\}, \{Laura J.\} and Sten Cornelissen and Rutgers, \{Emiel J.\} and Southey, \{Melissa C.\} and Carmel Apicella and Dite, \{Gillian S\} and Hopper, \{John L.\} and Fasching, \{Peter A.\} and Lothar Haeberle and Ekici, \{Arif B\} and Beckmann, \{Matthias W.\} and Carl Blomqvist and Muranen, \{Taru A.\} and Kristiina Aittom{\"a}ki and Annika Lindblom and Sara Margolin and Arto Mannermaa and Veli-Matti Kosma and Hartikainen, \{Jaana M.\} and Vesa Kataja and Georgia Chenevix-Trench and Kelly-Anne Phillips and Sue-Anne McLachlan and Diether Lambrechts and Bernard Thienpont and Ann Smeets and Hans Wildiers and Jenny Chang-Claude and Dieter Flesch-Janys and Petra Seibold and Anja Rudolph and Giles, \{Graham G.\} and Laura Baglietto and Gianluca Severi and Haiman, \{Christopher A\} and Henderson, \{Brian E\} and Fredrick Schumacher and \{Le Marchand\}, Loic and Vessela Kristensen and Aln{\ae}s, \{Grethe I.Grenaker\} and Anne-Lise Borresen-Dale and Silje Nord and Robert Winqvist and Katri Pylk{\"a}s and Arja Jukkola-Vuorinen and Mervi Grip and Andrulis, \{Irene L\} and Knight, \{Julia A\} and Gord Glendon and Sandrine Tchatchou and Peter Devilee and Tollenaar, \{Robert A.E.M.\} and Caroline Seynaeve and Hooning, \{Maartje J\} and Mieke Kriege and Antoinette Hollestelle and \{van den Ouweland\}, \{Ans M W\} and Yi Li and Ute Hamann and Diana Torres and Ulmer, \{Hans Ulrich\} and Thomas R{\"u}diger and Chen-Yang Shen and Chia-Ni Hsiung and Pei-Ei Wu and Shou-Tung Chen and Soo-Hwang Teo and Taib, \{Nur Aishah Mohd\} and \{Har Yip\}, Cheng and \{Fuang Ho\}, Gwo and Keitaro Matsuo and Hidemi Ito and Hiroji Iwata and Kazuo Tajima and Daehee Kang and Choi, \{Ji Yeob\} and Park, \{Sue K.\} and Keun-Young Yoo and Tom Maishman and Tapper, \{William J\} and Dunning, \{Alison M\} and Mitul Shah and Robert Luben and Judith Brown and \{Chuen Khor\}, Chiea and Eccles, \{Diana M\} and Heli Nevanlinna and Easton, \{Douglas F\} and Keith Humphreys and Jianjun Liu and Per Hall and Kamila Czene and \{kConFab Investigators\}",

year = "2014",

month = jun,

day = "17",

doi = "10.1038/ncomms5051",

language = "English",

volume = "5",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "Nature Publishing Group",

}

Li, J, Lindström, LS, Foo, JN, Rafiq, S, Schmidt, MK, Pharoah, PDP, Michailidou, K, Dennis, J, Bolla, MK, Wang, Q, Van't Veer, LJ, Cornelissen, S, Rutgers, EJ, Southey, MC, Apicella, C, Dite, GS, Hopper, JL, Fasching, PA, Haeberle, L, Ekici, AB, Beckmann, MW, Blomqvist, C, Muranen, TA, Aittomäki, K, Lindblom, A, Margolin, S, Mannermaa, A, Kosma, V-M, Hartikainen, JM, Kataja, V, Chenevix-Trench, G, Phillips, K-A, McLachlan, S-A, Lambrechts, D, Thienpont, B, Smeets, A, Wildiers, H, Chang-Claude, J, Flesch-Janys, D, Seibold, P, Rudolph, A, Giles, GG, Baglietto, L, Severi, G, Haiman, CA, Henderson, BE, Schumacher, F, Le Marchand, L, Kristensen, V, Alnæs, GIG, Borresen-Dale, A-L, Nord, S, Winqvist, R, Pylkäs, K, Jukkola-Vuorinen, A, Grip, M, Andrulis, IL, Knight, JA, Glendon, G, Tchatchou, S, Devilee, P, Tollenaar, RAEM, Seynaeve, C, Hooning, MJ, Kriege, M, Hollestelle, A, van den Ouweland, AMW, Li, Y, Hamann, U, Torres, D, Ulmer, HU, Rüdiger, T, Shen, C-Y, Hsiung, C-N, Wu, P-E, Chen, S-T, Teo, S-H, Taib, NAM, Har Yip, C, Fuang Ho, G, Matsuo, K, Ito, H, Iwata, H, Tajima, K, Kang, D, Choi, JY, Park, SK, Yoo, K-Y, Maishman, T, Tapper, WJ, Dunning, AM, Shah, M, Luben, R, Brown, J, Chuen Khor, C, Eccles, DM, Nevanlinna, H, Easton, DF, Humphreys, K, Liu, J, Hall, P, Czene, K & kConFab Investigators 2014, '2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy', Nature Communications, vol. 5, 4051. https://doi.org/10.1038/ncomms5051

TY - JOUR

T1 - 2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy

AU - Li, Jingmei

AU - Lindström, Linda S.

AU - Foo, Jia Nee

AU - Rafiq, Sajjad

AU - Schmidt, Marjanka K.

AU - Pharoah, Paul D P

AU - Michailidou, Kyriaki

AU - Dennis, Joe

AU - Bolla, Manjeet K.

AU - Wang, Qin

AU - Van't Veer, Laura J.

AU - Cornelissen, Sten

AU - Rutgers, Emiel J.

AU - Southey, Melissa C.

AU - Apicella, Carmel

AU - Dite, Gillian S

AU - Hopper, John L.

AU - Fasching, Peter A.

AU - Haeberle, Lothar

AU - Ekici, Arif B

AU - Beckmann, Matthias W.

AU - Blomqvist, Carl

AU - Muranen, Taru A.

AU - Aittomäki, Kristiina

AU - Lindblom, Annika

AU - Margolin, Sara

AU - Mannermaa, Arto

AU - Kosma, Veli-Matti

AU - Hartikainen, Jaana M.

AU - Kataja, Vesa

AU - Chenevix-Trench, Georgia

AU - Phillips, Kelly-Anne

AU - McLachlan, Sue-Anne

AU - Lambrechts, Diether

AU - Thienpont, Bernard

AU - Smeets, Ann

AU - Wildiers, Hans

AU - Chang-Claude, Jenny

AU - Flesch-Janys, Dieter

AU - Seibold, Petra

AU - Rudolph, Anja

AU - Giles, Graham G.

AU - Baglietto, Laura

AU - Severi, Gianluca

AU - Haiman, Christopher A

AU - Henderson, Brian E

AU - Schumacher, Fredrick

AU - Le Marchand, Loic

AU - Kristensen, Vessela

AU - Alnæs, Grethe I.Grenaker

AU - Borresen-Dale, Anne-Lise

AU - Nord, Silje

AU - Winqvist, Robert

AU - Pylkäs, Katri

AU - Jukkola-Vuorinen, Arja

AU - Grip, Mervi

AU - Andrulis, Irene L

AU - Knight, Julia A

AU - Glendon, Gord

AU - Tchatchou, Sandrine

AU - Devilee, Peter

AU - Tollenaar, Robert A.E.M.

AU - Seynaeve, Caroline

AU - Hooning, Maartje J

AU - Kriege, Mieke

AU - Hollestelle, Antoinette

AU - van den Ouweland, Ans M W

AU - Li, Yi

AU - Hamann, Ute

AU - Torres, Diana

AU - Ulmer, Hans Ulrich

AU - Rüdiger, Thomas

AU - Shen, Chen-Yang

AU - Hsiung, Chia-Ni

AU - Wu, Pei-Ei

AU - Chen, Shou-Tung

AU - Teo, Soo-Hwang

AU - Taib, Nur Aishah Mohd

AU - Har Yip, Cheng

AU - Fuang Ho, Gwo

AU - Matsuo, Keitaro

AU - Ito, Hidemi

AU - Iwata, Hiroji

AU - Tajima, Kazuo

AU - Kang, Daehee

AU - Choi, Ji Yeob

AU - Park, Sue K.

AU - Yoo, Keun-Young

AU - Maishman, Tom

AU - Tapper, William J

AU - Dunning, Alison M

AU - Shah, Mitul

AU - Luben, Robert

AU - Brown, Judith

AU - Chuen Khor, Chiea

AU - Eccles, Diana M

AU - Nevanlinna, Heli

AU - Easton, Douglas F

AU - Humphreys, Keith

AU - Liu, Jianjun

AU - Hall, Per

AU - Czene, Kamila

AU - kConFab Investigators

PY - 2014/6/17

Y1 - 2014/6/17

N2 - Large population-based registry studies have shown that breast cancer prognosis is inherited. Here we analyse single-nucleotide polymorphisms (SNPs) of genes implicated in human immunology and inflammation as candidates for prognostic markers of breast cancer survival involving 1,804 oestrogen receptor (ER)-negative patients treated with chemotherapy (279 events) from 14 European studies in a prior large-scale genotyping experiment, which is part of the Collaborative Oncological Gene-environment Study (COGS) initiative. We carry out replication using Asian COGS samples (n=522, 53 events) and the Prospective Study of Outcomes in Sporadic versus Hereditary breast cancer (POSH) study (n=315, 108 events). Rs4458204-A near CCL20 (2q36.3) is found to be associated with breast cancer-specific death at a genome-wide significant level (n=2,641, 440 events, combined allelic hazard ratio (HR)=1.81 (1.49-2.19); P for trend=1.90 × 10 â ̂'9). Such survival-associated variants can represent ideal targets for tailored therapeutics, and may also enhance our current prognostic prediction capabilities.

AB - Large population-based registry studies have shown that breast cancer prognosis is inherited. Here we analyse single-nucleotide polymorphisms (SNPs) of genes implicated in human immunology and inflammation as candidates for prognostic markers of breast cancer survival involving 1,804 oestrogen receptor (ER)-negative patients treated with chemotherapy (279 events) from 14 European studies in a prior large-scale genotyping experiment, which is part of the Collaborative Oncological Gene-environment Study (COGS) initiative. We carry out replication using Asian COGS samples (n=522, 53 events) and the Prospective Study of Outcomes in Sporadic versus Hereditary breast cancer (POSH) study (n=315, 108 events). Rs4458204-A near CCL20 (2q36.3) is found to be associated with breast cancer-specific death at a genome-wide significant level (n=2,641, 440 events, combined allelic hazard ratio (HR)=1.81 (1.49-2.19); P for trend=1.90 × 10 â ̂'9). Such survival-associated variants can represent ideal targets for tailored therapeutics, and may also enhance our current prognostic prediction capabilities.

UR - https://www.scopus.com/pages/publications/84902763179

U2 - 10.1038/ncomms5051

DO - 10.1038/ncomms5051

M3 - Article

C2 - 24937182

AN - SCOPUS:84902763179

SN - 2041-1723

VL - 5

JO - Nature Communications

JF - Nature Communications

M1 - 4051

ER -

2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy

Abstract

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