2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-6][1,5]benzodiazepine methanol solvate monohydrate

Benny Capuano, Ian Travers Crosby, Gary D Fallon, Edward John Lloyd, Elizabeth Yuriev, S Egan

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Abstract

The thienobenzodiazepine nucleus of the title compound, olanzapine methanol solvate monohydrate, C17H20N4S·CH 4O·H2O, is buckled, with the central seven-membered heterocycle in a boat conformation and the dihedral angle between the planes of the aromatic rings being 118°. The piperazine ring displays an almost perfect chair conformation with the methyl group assuming an equatorial orientation. The relative position of the thienobenzodiazepine and piperazine ring system is controlled by the planarity of the piperazine N in the amidine moiety.

Original languageEnglish
Pages (from-to)1367-1369
Number of pages3
JournalActa Crystallographica Section E: Structure Reports Online
Volume59
Issue number9
DOIs
Publication statusPublished - 1 Sep 2003

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