2′ Biaryl amides as novel and subtype selective M1 agonists. Part I: Identification, synthesis, and initial SAR

Brian Budzik, Vincenzo Garzya, Dongchuan Shi, James J. Foley, Ralph A. Rivero, Christopher J. Langmead, Jeannette M Watson, Zining Wu, Ian T Forbes, JIan Jin

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14 Citations (Scopus)

Abstract

Biaryl amides were discovered as novel and subtype selective M1 muscarinic acetylcholine receptor agonists. The identification, synthesis, and initial structure-activity relationships that led to compounds 3j and 4c, possessing good M1 agonist potency and intrinsic activity, and subtype selectivity for M1 over M2-5, are described.

Original languageEnglish
Pages (from-to)3540-3544
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume20
Issue number12
DOIs
Publication statusPublished - 2010
Externally publishedYes

Keywords

  • 2′ Biaryl amides
  • Novel M1 agonists
  • Subtype selective M1 muscarinic acetylcholine receptor agonist

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