Abstract
Reaction of N-alkyl-N-arylsulfonyl-2-halo-propionamides with pentamethyldiethylenetriamine and either CuBr or CuCl leads to 2-aryl propionamides via initial radical generation, 1,4-aryl migration with loss of SO2 and reduction of the intermediate amidyl radical in 40-99% yields.
Original language | English |
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Pages (from-to) | 6311-6314 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 50 |
Issue number | 46 |
DOIs | |
Publication status | Published - 18 Nov 2009 |
Externally published | Yes |
Keywords
- Aryl migration
- Atom transfer
- ATRC
- Copper
- Dimethylpiperazine
- Radical