2-aminobenzaldehydes as versatile substrates for rhodium-catalyzed alkyne hydroacylation: Application to dihydroquinolone synthesis

Matthias Castaing, Sacha L. Wason, Beatriz Estepa, Joel F. Hooper, Michael C. Willis

Research output: Contribution to journalArticleResearchpeer-review

65 Citations (Scopus)


Amine for it! A cationic rhodium catalyst, which was assembled insitu from commercial components, promoted the reaction of a range of simple 2-aminobenzaldehydes with terminal and internal alkynes in a series of intermolecular hydroacylation reactions. The products of this reaction, amino-substituted enones, were efficiently converted into the corresponding dihydro-4-quinolones.

Original languageEnglish
Pages (from-to)13280-13283
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number50
Publication statusPublished - 9 Dec 2013
Externally publishedYes


  • aldehydes
  • amines
  • dihydroquinolones
  • enones
  • rhodium catalysis

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