γ-radiation-induced γh2AX formation occurs preferentially in actively transcribing euchromatic loci

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Abstract

The central dogma in radiation biology is that nuclear DNA is the critical target with respect to radiosensitivity. In accordance with the theoretical expectations, and in the absence of a conclusive model, the general consensus in the field has been to view chromatin as a homogeneous template for DNA damage and repair. This paradigm has been called into question by recent findings indicating a disparity in γ-irradiation-induced γH2AX foci formation in euchromatin and heterochromatin. Here, we have extended those studies and provide evidence that γH2AX foci form preferentially in actively transcribing euchromatin following γ-irradiation.

Original languageEnglish
Pages (from-to)291-294
Number of pages4
JournalCellular and Molecular Life Sciences
Volume67
Issue number2
DOIs
Publication statusPublished - Jan 2010
Externally publishedYes

Keywords

  • γ-Radiation
  • γH2AX
  • Double strand break
  • Euchromatin
  • Heterochromatin
  • Histone methylation

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