β2-Microglobulin clearance with super high flux hemodialysis: An ex vivo study

W. C.R. Lee, S. Uchino, N. Fealy, I. Baldwin, S. Panagiotopoulos, H. Goehl, S. Morgera, H. H. Neumayer, Rinaldo Bellomo

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7 Citations (Scopus)

Abstract

Background: β2m accumulation induces disease in patients with end-stage renal failure (ESRF). Thus, its removal from patients with ESRF appears desirable. Current dialysis technology, however, has limited effectiveness. Aims: To measure β2m clearance with a novel super high flux membrane. Design: Ex vivo experimental study. Setting: Intensive Care Laboratory of Tertiary institution. Subjects: Six volunteers. Measurements and Results: At a blood flow of 300 ml/min, the clearance of β2-MG increased from 113.5 ± 38.5 ml/min with a dialysate flow rate of 200 ml/min to 184.8 ± 61.1 ml/min with a flow rate of 300 ml/min and 195.0 ± 60.0 ml/min with a 500 ml/min flow rate. The clearance of albumin was 4.5 ml/min with a dialysate flow rate of 200 ml/min, 5.2 ml/min for a flow rate of 300 ml/min and 5.8 ml/min for a flow rate of 500 ml/min. Conclusions: High levels of β2m clearance can be achieved with a super high flux membrane while albumin losses remain limited.

Original languageEnglish
Pages (from-to)723-727
Number of pages5
JournalInternational Journal of Artificial Organs
Volume26
Issue number8
Publication statusPublished - 1 Aug 2003
Externally publishedYes

Keywords

  • Albumin
  • Beta-microglobulin
  • Clearance
  • End-stage renal failure
  • Hemodialysis
  • Super high flux membranes

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