β-Amyloid burden in the temporal neocortex is related to hippocampal atrophy in elderly subjects without dementia

P. Bourgeat, G. Chételat, V. L. Villemagne, J. Fripp, P. Raniga, K. Pike, O. Acosta, C. Szoeke, S. Ourselin, D. Ames, K. A. Ellis, R. N. Martins, C. L. Masters, C. C. Rowe, O. Salvado

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Abstract

Objective: To investigate whether global and regional β-amyloid (Aβ) burden as measured with C Pittsburgh compound B (PIB) PET is associated with hippocampal atrophy characterized using MRI in healthy controls and patients with amnestic mild cognitive impairment (aMCI) or Alzheimer disease (AD). METHODS: Ninety-two elderly healthy controls, 32 subjects with aMCI, and 35 patients with AD were imaged using C-PIB PET and MRI. Hippocampal volume was measured and PIB standardized uptake value ratio was extracted after partial volume correction within 41 regions of interest. Global, regional, and voxel-based correlations between PIB and hippocampal volume were computed for each group. RESULTS: In healthy control participants with elevated neocortex PIB retention, significant correlation was found between PIB retention in the inferior temporal region and hippocampal volume using both region-based and voxel-based approaches. No correlation was found in any other group. CONCLUSIONS: The strong correlation between hippocampal atrophy and β-amyloid (Aβ) burden in the Pittsburgh compound B-positive healthy control group suggests that Aβ deposition in the inferior temporal neocortex is related to hippocampal synaptic and neuronal degeneration.

Original languageEnglish
Pages (from-to)121-127
Number of pages7
JournalNeurology
Volume74
Issue number2
DOIs
Publication statusPublished - Jan 2010
Externally publishedYes

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