β-Amyloid, APOE and BDNF Genotype, and Depressive and Anxiety Symptoms in Cognitively Normal Older Women and Men

Sophie E. Holmes, Irina Esterlis, Carolyn M. Mazure, Yen Ying Lim, David Ames, Stephanie Rainey-Smith, Ralph N. Martins, Olivier Salvado, Vincent Dore, Victor L. Villemagne, Christopher C. Rowe, Simon M. Laws, Colin L. Masters, Paul Maruff, Robert H. Pietrzak

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Abstract

Objective To examine how β-amyloid (Aβ), APOE and BDNF genotypes, and cortisol relate to depressive and anxiety symptoms in cognitively normal older women and men. Methods Cross-sectional data were analyzed from 423 older adults from the Australian Imaging Biomarkers and Lifestyle study. Analyses of covariance evaluated associations between Aβ, APOE and BDNF genotype, and cortisol in relation to severity of depressive and anxiety symptoms. Results Among Aβ+ older adults, APOE ε4 carriage was associated with greater severity of anxiety symptoms (d = 0.55); and in the full sample, APOE ε4 carriage was linked to greater severity of depressive (d = 0.26) and anxiety (d = 0.21) symptoms. Among Aβ+ women, ε4 carriers reported greater anxiety symptoms than non-ε4 carriers (d = 0.83), and female BDNF rs6265 Val66 Met allele carriers reported greater depressive symptoms (d = 0.29). Conclusion Sex moderated the relationship between Aβ, APOE genotype, and BDNF genotype in predicting severity of anxiety and depressive symptoms in cognitively normal older adults.

Original languageEnglish
Pages (from-to)1191-1195
Number of pages5
JournalThe American Journal of Geriatric Psychiatry
Volume24
Issue number12
DOIs
Publication statusPublished - Dec 2016
Externally publishedYes

Keywords

  • amyloid
  • anxiety
  • APOE
  • BDNF
  • depression
  • elderly

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