Abstract
Quantitative autoradiography was used to determine the density and distribution of β1- and β2-adrenoceptors in the atrioventricular (AV) conducting system and surrounding myocardium of spontaneously hypertensive rats (SHR) after chronic infusion of perindopril (1 mg/kg/day) for 14 days by osmotic mini-pumps. Systolic blood pressure (SBP) was measured for a period of 4 weeks (2 weeks before and 2 weeks during perindopril infusion) in control and treated animals. Animals infused with vehicle (water) had a mean SBP of 248 mm Hg (measured on day 29); animals treated with perindopril had lower SBP (121 mm Hg, day 29). Perindopril treatment also prevented development of cardiac hypertrophy in SHR. β-Adrenoceptor densities were measured in the AV node, His bundle, left and right bundle branches (LB, BB), interventricular and interatrial septa (IVS, IAS), mitral valve (MV), right papillary muscle, left and right ventricles (LV, RV), left and right atria (LA, RA), and apex. Perindopril produced no significant change in β-adrenoceptors in any cardiac region examined. The results suggest that under experimental conditions in which perindopril treatment prevented cardiac hypertrophy and decreased SBP, there was no significant interaction between the renin-angiotensin system (RAS) and β-adrenoceptor system in rat heart.
| Original language | English |
|---|---|
| Pages (from-to) | 691-697 |
| Number of pages | 7 |
| Journal | Journal of Cardiovascular Pharmacology |
| Volume | 23 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 1 Jan 1994 |
Keywords
- Angiotensin-converting enzyme inhibition
- Autoradiography, β1- and β2-adrenoceptors
- Cardiac hypertrophy
- Receptor regulation
- Spontaneously hypertensive rat
Cite this
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β-adrenoceptor subtypes in the atrioventricular conducting system and myocardium of spontaneously hypertensive rats : Effects of angiotensin-converting enzyme inhibition by perindopril. / Matthews, Janine M.; Molenaar, Peter; Summers, Roger J.
In: Journal of Cardiovascular Pharmacology, Vol. 23, No. 5, 01.01.1994, p. 691-697.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - β-adrenoceptor subtypes in the atrioventricular conducting system and myocardium of spontaneously hypertensive rats
T2 - Effects of angiotensin-converting enzyme inhibition by perindopril
AU - Matthews, Janine M.
AU - Molenaar, Peter
AU - Summers, Roger J.
PY - 1994/1/1
Y1 - 1994/1/1
N2 - Quantitative autoradiography was used to determine the density and distribution of β1- and β2-adrenoceptors in the atrioventricular (AV) conducting system and surrounding myocardium of spontaneously hypertensive rats (SHR) after chronic infusion of perindopril (1 mg/kg/day) for 14 days by osmotic mini-pumps. Systolic blood pressure (SBP) was measured for a period of 4 weeks (2 weeks before and 2 weeks during perindopril infusion) in control and treated animals. Animals infused with vehicle (water) had a mean SBP of 248 mm Hg (measured on day 29); animals treated with perindopril had lower SBP (121 mm Hg, day 29). Perindopril treatment also prevented development of cardiac hypertrophy in SHR. β-Adrenoceptor densities were measured in the AV node, His bundle, left and right bundle branches (LB, BB), interventricular and interatrial septa (IVS, IAS), mitral valve (MV), right papillary muscle, left and right ventricles (LV, RV), left and right atria (LA, RA), and apex. Perindopril produced no significant change in β-adrenoceptors in any cardiac region examined. The results suggest that under experimental conditions in which perindopril treatment prevented cardiac hypertrophy and decreased SBP, there was no significant interaction between the renin-angiotensin system (RAS) and β-adrenoceptor system in rat heart.
AB - Quantitative autoradiography was used to determine the density and distribution of β1- and β2-adrenoceptors in the atrioventricular (AV) conducting system and surrounding myocardium of spontaneously hypertensive rats (SHR) after chronic infusion of perindopril (1 mg/kg/day) for 14 days by osmotic mini-pumps. Systolic blood pressure (SBP) was measured for a period of 4 weeks (2 weeks before and 2 weeks during perindopril infusion) in control and treated animals. Animals infused with vehicle (water) had a mean SBP of 248 mm Hg (measured on day 29); animals treated with perindopril had lower SBP (121 mm Hg, day 29). Perindopril treatment also prevented development of cardiac hypertrophy in SHR. β-Adrenoceptor densities were measured in the AV node, His bundle, left and right bundle branches (LB, BB), interventricular and interatrial septa (IVS, IAS), mitral valve (MV), right papillary muscle, left and right ventricles (LV, RV), left and right atria (LA, RA), and apex. Perindopril produced no significant change in β-adrenoceptors in any cardiac region examined. The results suggest that under experimental conditions in which perindopril treatment prevented cardiac hypertrophy and decreased SBP, there was no significant interaction between the renin-angiotensin system (RAS) and β-adrenoceptor system in rat heart.
KW - Angiotensin-converting enzyme inhibition
KW - Autoradiography, β1- and β2-adrenoceptors
KW - Cardiac hypertrophy
KW - Receptor regulation
KW - Spontaneously hypertensive rat
UR - http://www.scopus.com/inward/record.url?scp=0028327441&partnerID=8YFLogxK
U2 - 10.1097/00005344-199405000-00001
DO - 10.1097/00005344-199405000-00001
M3 - Article
VL - 23
SP - 691
EP - 697
JO - Journal of Cardiovascular Pharmacology
JF - Journal of Cardiovascular Pharmacology
SN - 0160-2446
IS - 5
ER -