α-Eleostearic acid is more effectively metabolized into conjugated linoleic acid than punicic acid in mice

Gao Feng Yuan, Andrew J. Sinclair, Ci Qin Zhou, Duo Li

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28 Citations (Scopus)

Abstract

BACKGROUND: The objective of this study was to investigate the metabolism of α-eleostearic acid (α-ESA, cis 9, trans 11, tran s13-18: 3) and punicic acid (PA, cis 9, trans11, cis13-18: 3) and to compare the relative conversion efficiency of these fatty acids into conjugated linoleic acids (CLAs) in mice. RESULTS: Twenty-four male ICR mice were fed either a control diet or one of two experimental diets supplemented with 10 g kg-1 α-ESA or PA in the form of triacylglycerols for 6 weeks. The accumulation of PA in all tissues examined was significantly higher thanα-ESA; in both groups it was found thatcis9, trans11-conjugated linoleic acid (cis9, trans 11-18: 2) was detected in all tissues examined. The relative conversion rate ofα-ESA intocis9, trans11-18: 2 was significantly higher than that of PA. The highest conversion rate ofα-ESA was found in adipose tissue (91.8%), spleen (91.4%) and kidney (90.7%), and the lowest in the heart (84.6%). The highest conversion rate of PA occurred in the liver (76.2%) and the lowest occurred in the heart (54.5%). CONCLUSION: The present results indicate that bothα-ESA and PA are effectively metabolized intocis9, trans11-18: 2 in mice. These conjugated dietary fatty acids might be useful sources of CLAs in tissues owing to the natural abundance ofα-ESA and PA in some seeds.

Original languageEnglish
Pages (from-to)1006-1011
Number of pages6
JournalJournal of the Science of Food and Agriculture
Volume89
Issue number6
DOIs
Publication statusPublished - 1 Apr 2009
Externally publishedYes

Keywords

  • α-eleostearic acid
  • Conjugated linoleic acid
  • Conjugated linolenic acid
  • Metabolism
  • Punicic acid

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