Using protein structure and dynamics to facilitate drug discovery

Thal, David (Primary Chief Investigator (PCI))

Drug Discovery Biology

Project: Research

Status	Finished
Effective start/end date	1/01/21 → 31/12/25

Keywords

G protein-coupled receptors
structural biology
X-ray crystallography
pharmacology
drug discovery

Molecular basis of ligand binding and receptor activation at the human A₃ adenosine receptor
Zhang, L., Mobbs, J. I., Bennetts, F. M., Venugopal, H., Nguyen, A. T. N., Christopoulos, A., van der Es, D., Heitman, L. H., May, L. T., Glukhova, A. & Thal, D. M., Dec 2025, In: Nature Communications. 16, 1, 19 p., 7674.
Research output: Contribution to journal › Article › Research › peer-review

Open Access

1 Link opens in a new tab Citation (Scopus)
The Prosperity and Adversity of M₄ Muscarinic Acetylcholine Receptor Activators in the Treatment of Neuropsychiatric Disorders
Liu, B., Christopoulos, A., Thal, D. M., Capuano, B., Valant, C. & Scammells, P. J., 16 Apr 2025, In: Journal of Medicinal Chemistry. 68, 8, p. 7932–7954 23 p.
Research output: Contribution to journal › Review Article › Research › peer-review
Importance of receptor expression in the classification of novel ligands at the M₂ muscarinic acetylcholine receptor
Jiang, Y., Yeasmin, M., Gondin, A. B., Christopoulos, A., Valant, C., Burger, W. A. C. & Thal, D. M., Jul 2024, In: British Journal of Pharmacology. 181, 14, p. 2338-2350 13 p.
Research output: Contribution to journal › Article › Research › peer-review

Open Access

9 Link opens in a new tab Citations (Scopus)