The skin provides a window into the biology of our cells and a model by which to study organ development.
This application will use the mouse to model the development of the epidermis, the outermost protective cell
layer of the skin. I will study several genes import for embryonic skin development and explore their further
functional roles in regulating the development and maintenance of other organs. In collaboration with
international researchers I will use cutting edge mouse genetics to identify new genes which control skin
development. These studies will identify and characterise genes fundamental to the biology of the cell and
delineate their causative roles in diseases of the skin, cardiovascular system and developing face.