Unveiling the epigenome dynamics through the pluripotency continuum

In this project we will utilise stem cells and genomics based technologies, in combination with new computational algorithms, to dissect the fundamental molecular events that drives the first steps during development. Our results will unveil the basic mechanisms underpinning how genes driving the developmental master plan are controlled in cells that have the capacity to give rise to the whole organism and placenta. Therefore the knowledge gained through this research program will be advantageous for future applications in assisted reproductive technologies, drug screening approaches and Regenerative Medicine.