Understanding the genetic regulation of embryo formation is the cornerstone of developmental biology. As 4% of Australian children are born with some form of pre-natal defect, understanding the basic biology of embryogenesis is paramount for long-range development of future therapies. We have identified a highly conserved transcription factor, Grhl3, which regulates multiple stages of embryonic formation. Using advanced genetic models, I will characterise the role of Grhl3 in the regulation of cellular migration, craniofacial skeleton and brain development, and will identify the target genes which it regulates. The identification of such transcriptional networks is imperative to understanding the holistic molecular control of embryogenesis.
|Effective start/end date||25/01/14 → 31/12/17|
- Australian Research Council (ARC): AUD275,220.00
- Australian Research Council (ARC): AUD107,846.00