Unique and selective small molecules to dissect histone acetyltransferase biology

Baell, Jonathan (Primary Chief Investigator (PCI))
Thomas, Tim (Chief Investigator (CI))
Parker, Michael (Associate Investigator (AI))

Medicinal Chemistry

Project: Research

Status	Finished
Effective start/end date	1/01/15 → 31/12/18

Funding

National Health and Medical Research Council (NHMRC) (Australia): A$672,451.00

2 Article
1 Letter

Discovery of Potent and Fast-Acting Antimalarial Bis-1,2,4-triazines
Priebbenow, D. L., Mathiew, M., Shi, D. H., Harjani, J. R., Beveridge, J. G., Chavchich, M., Edstein, M. D., Duffy, S., Avery, V. M., Jacobs, R. T., Brand, S., Shackleford, D. M., Wang, W., Zhong, L., Lee, G., Tay, E., Barker, H., Crighton, E., White, K. L., Charman, S. A., & 3 othersDe Paoli, A., Creek, D. J. & Baell, J. B., 8 Apr 2021, In: Journal of Medicinal Chemistry. 64, 7, p. 4150-4162 13 p.
Research output: Contribution to journal › Article › Research › peer-review

14 Citations (Scopus)
Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents
Priebbenow, D. L., Leaver, D. J., Nguyen, N., Cleary, B., Lagiakos, H. R., Sanchez, J., Xue, L., Huang, F., Sun, Y., Mujumdar, P., Mudududdla, R., Varghese, S., Teguh, S., Charman, S. A., White, K. L., Shackleford, D. M., Katneni, K., Cuellar, M., Strasser, J. M., Dahlin, J. L., & 13 othersWalters, M. A., Street, I. P., Monahan, B. J., Jarman, K. E., Jousset Sabroux, H., Falk, H., Chung, M. C., Hermans, S. J., Downer, N. L., Parker, M. W., Voss, A. K., Thomas, T. & Baell, J. B., 14 May 2020, In: Journal of Medicinal Chemistry. 63, 9, p. 4655-4684 30 p.
Research output: Contribution to journal › Article › Research › peer-review

10 Citations (Scopus)
Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth
Baell, J. B., Leaver, D. J., Hermans, S. J., Kelly, G. L., Brennan, M. S., Downer, N. L., Nguyen, N., Wichmann, J., McRae, H. M., Yang, Y., Cleary, B., Lagiakos, H. R., Mieruszynski, S., Pacini, G., Vanyai, H. K., Bergamasco, M. I., May, R. E., Davey, B. K., Morgan, K. J., Sealey, A. J., & 32 othersWang, B., Zamudio, N., Wilcox, S., Garnham, A. L., Sheikh, B. N., Aubrey, B. J., Doggett, K., Chung, M. C., de Silva, M., Bentley, J., Pilling, P., Hattarki, M., Dolezal, O., Dennis, M. L., Falk, H., Ren, B., Charman, S. A., White, K. L., Rautela, J., Newbold, A., Hawkins, E. D., Johnstone, R. W., Huntington, N. D., Peat, T. S., Heath, J. K., Strasser, A., Parker, M. W., Smyth, G. K., Street, I. P., Monahan, B. J., Voss, A. K. & Thomas, T., 9 Aug 2018, In: Nature. 560, 7717, p. 253-257 5 p.
Research output: Contribution to journal › Letter › Research › peer-review

Open Access
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195 Citations (Scopus)

Unique and selective small molecules to dissect histone acetyltransferase biology

Project Details

Funding

Research output

Discovery of Potent and Fast-Acting Antimalarial Bis-1,2,4-triazines

Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents

Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth