Understanding the physiological consequences of biased signalling mediated by the glucagon-like peptide-1 receptor

Research output

Research output per year 2015 2016 2017 2018 2019

• 13 Article
• 2 Review Article

Research output per year

Research output per year

Search results

• 2019

  Expression and activity of the calcitonin receptor family in a sample of primary human high-grade gliomas

  Ostrovskaya, A., Hick, C., Hutchinson, D. S., Stringer, B. W., Wookey, P. J., Wootten, D., Sexton, P. M. & Furness, S. G. B., 18 Feb 2019, In: BMC Cancer. 19, 1, 12 p., 157.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

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  12 Citations (Scopus)
• 2018

  Differential engagement of polar networks in the glucagon-like peptide 1 receptor by endogenous variants of the glucagon-like peptide 1

  Furness, S. G. B., Christopoulos, A., Sexton, P. M. & Wootten, D., 1 Oct 2018, In: Biochemical Pharmacology. 156, p. 223-240 18 p.

  Research output: Contribution to journal › Article › Research › peer-review
  6 Citations (Scopus)

• Extracellular loops 2 and 3 of the calcitonin receptor selectively modify agonist binding and efficacy

  Dal Maso, E., Zhu, Y., Pham, V., Reynolds, C. A., Deganutti, G., Hick, C. A., Yang, D., Christopoulos, A., Hay, D. L., Wang, M. W., Sexton, P. M., Furness, S. G. B. & Wootten, D., 1 Apr 2018, In: Biochemical Pharmacology. 150, p. 214-244 31 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

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  23 Citations (Scopus)

• Glucagon-like peptide-1 receptor internalisation controls spatiotemporal signalling mediated by biased agonists

  Fletcher, M. M., Halls, M. L., Zhao, P., Clydesdale, L., Christopoulos, A., Sexton, P. M. & Wootten, D., 1 Oct 2018, In: Biochemical Pharmacology. 156, p. 406-419 14 p.

  Research output: Contribution to journal › Article › Research › peer-review
  33 Citations (Scopus)

• Phase-plate cryo-EM structure of a biased agonistbound human GLP-1 receptor-Gs complex

  Liang, Y. L., Khoshouei, M., Glukhova, A., Furness, S. G. B., Zhao, P., Clydesdale, L., Koole, C., Truong, T. T., Thal, D. M., Lei, S., Radjainia, M., Danev, R., Baumeister, W., Wang, M. W., Miller, L. J., Christopoulos, A., Sexton, P. M. & Wootten, D., 1 Mar 2018, In: Nature. 555, 7694, p. 121-125 5 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

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  217 Citations (Scopus)

• Two distinct domains of the glucagon-like peptide-1 receptor control peptide-mediated biased agonism

  Lei, S., Clydesdale, L., Dai, A., Cai, X., Yang, F., Yang, D., Liang, Y-L., Koole, C., Zhao, P., Coudrat, T., Christopoulos, A., Wang, M-W., Wootten, D. & Sexton, P. M., 1 Jan 2018, In: Journal of Biological Chemistry. 293, 24, p. 9370-9387 18 p.

  Research output: Contribution to journal › Article › Research › peer-review
  36 Citations (Scopus)
• 2017

  Allostery and Biased Agonism at Class B G Protein-Coupled Receptors

  Wootten, D., Miller, L. J., Koole, C., Christopoulos, A. & Sexton, P. M., 11 Jan 2017, In: Chemical Reviews. 117, 1, p. 111-138 28 p.

  Research output: Contribution to journal › Review Article › Research › peer-review
  84 Citations (Scopus)

• Characterization of signal bias at the GLP-1 receptor induced by backbone modification of GLP-1

  Hager, M. V., Clydesdale, L., Gellman, S. H., Sexton, P. M. & Wootten, D., 15 Jul 2017, In: Biochemical Pharmacology. 136, p. 99-108 10 p.

  Research output: Contribution to journal › Article › Research › peer-review
  48 Citations (Scopus)

• Coexpressed class B G protein-coupled secretin and GLP-1 receptors self- and cross-associate: impact on pancreatic islets

  Harikumar, K. G., Lau, S., Sexton, P. M., Wootten, D. & Miller, L. J., 1 Jun 2017, In: Endocrinology. 158, 6, p. 1685-1700 16 p.

  Research output: Contribution to journal › Article › Research › peer-review
  6 Citations (Scopus)
• 2016

  A hydrogen-bonded polar network in the core of the glucagon-like peptide-1 receptor is a fulcrum for biased agonism: lessons from class B crystal structuress

  Wootten, D., Reynolds, C. A., Koole, C., Smith, K. J., Mobarec, J. C., Simms, J., Quon, T., Coudrat, T., Furness, S. G. B., Miller, L. J., Christopoulos, A. & Sexton, P. M., 1 Mar 2016, In: Molecular Pharmacology. 89, 3, p. 335-347 13 p.

  Research output: Contribution to journal › Article › Research › peer-review
  50 Citations (Scopus)

• Glucagon-like peptide-1 and its class B G protein-coupled receptors: a long march to therapeutic successes

  de Graaf, C., Donnelly, D., Wootten, D., Lau, J., Sexton, P. M., Miller, L. J., Ahn, J-M., Liao, J., Fletcher, M. M., Yang, D., Brown, A. J. H., Zhou, C., Deng, J. & Wang, M-W., 1 Oct 2016, In: Pharmacological Reviews. 68, 4, p. 954-1013 60 p.

  Research output: Contribution to journal › Review Article › Research › peer-review
  212 Citations (Scopus)

• Key interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in the glucagon-like peptide-1 receptor

  Wootten, D., Reynolds, C. A., Smith, K. J., Mobarec, J. C., Furness, S. G. B., Miller, L. J., Christopoulos, A. & Sexton, P. M., 15 Oct 2016, In: Biochemical Pharmacology. 118, p. 68-87 20 p.

  Research output: Contribution to journal › Article › Research › peer-review
  37 Citations (Scopus)

• The complexity of signalling mediated by the glucagon-like peptide-1 receptor

  Fletcher, M. M., Halls, M. L., Christopoulos, A., Sexton, P. M. & Wootten, D., 15 Apr 2016, In: Biochemical Society Transactions. 44, 2, p. 582-588 7 p.

  Research output: Contribution to journal › Article › Research › peer-review
  25 Citations (Scopus)

• β-arrestin-biased agonists of the GLP-1 receptor from β-amino acid residue incorporation into GLP-1 analogues

  Hager, M. V., Johnson, L. M., Wootten, D., Sexton, P. M. & Gellman, S. H., 16 Nov 2016, In: Journal of the American Chemical Society. 138, 45, p. 14970-14979 10 p.

  Research output: Contribution to journal › Article › Research › peer-review
  63 Citations (Scopus)
• 2015

  Differential impact of amino acid substitutions on critical residues of the human glucagon-like peptide-1 receptor involved in peptide activity and small-molecule allosterys

  Koole, C. R., Wootten, D. L., Simms, J. W., Miller, L. J., Christopoulos, A. & Sexton, P., 2015, In: Journal of Pharmacology and Experimental Therapeutics. 353, 1, p. 52 - 63 12 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

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  17 Citations (Scopus)