Understanding the cardio-protective actions of the AT2R in females: Shifting gears between AT1 and AT2 receptor balance of function with relaxin.

Denton, Katherine (Primary Chief Investigator (PCI))
Samuel, Chrishan (Chief Investigator (CI))
Widdop, Robert (Chief Investigator (CI))
Hewitson, Timothy (Chief Investigator (CI))
Pearson, James (Chief Investigator (CI))

Project: Research

5 Article
2 Review Article

7 results

2021

In Aged Females, the Enhanced Pressor Response to Angiotensin II Is Attenuated By Estrogen Replacement via an Angiotensin Type 2 Receptor-Mediated Mechanism
Barsha, G., Mirabito Colafella, K. M., Walton, S. L., Gaspari, T. A., Spizzo, I., Pinar, A. A., Hilliard Krause, L. M., Widdop, R. E., Samuel, C. S. & Denton, K. M., Jul 2021, In: Hypertension. 78, 1, p. 128-137 10 p.
Research output: Contribution to journal › Article › Research › peer-review

17 Citations (Scopus)
Relaxin Attenuates Organ Fibrosis via an Angiotensin Type 2 Receptor Mechanism in Aged Hypertensive Female Rats
Barsha, G., Walton, S., Kwok, E., Mirabito Colafella, K. M., Pinar, A. A., Hilliard Krause, L. M., Gaspari, T. A., Widdop, R. E., Samuel, C. S. & Denton, K. M., Nov 2021, In: Kidney360. 2, 11, p. 1781-1792 12 p.
Research output: Contribution to journal › Article › Research › peer-review

Open Access

12 Citations (Scopus)
2020

Serelaxin and the AT₂ Receptor Agonist CGP42112 Evoked a Similar, Nonadditive, Cardiac Antifibrotic Effect in High Salt-Fed Mice That Were Refractory to Candesartan Cilexetil
Wang, Y., Han, L., Shen, M., Jones, E. S., Spizzo, I., Walton, S. L., Denton, K. M., Gaspari, T. A., Samuel, C. S. & Widdop, R. E., 14 Feb 2020, In: ACS Pharmacology & Translational Science. 3, 1, p. 76-87 12 p.
Research output: Contribution to journal › Article › Research › peer-review

Open Access
File

19 Citations (Scopus)
The anti-fibrotic actions of relaxin are mediated through AT₂R-associated protein phosphatases via RXFP1-AT₂R functional crosstalk in human cardiac myofibroblasts
Wang, C., Pinar, A. A., Widdop, R. E., Hossain, M. A., Bathgate, R. A. D., Denton, K. M., Kemp-Harper, B. K. & Samuel, C. S., Jun 2020, In: The FASEB Journal. 34, 6, p. 8217-8233 17 p.
Research output: Contribution to journal › Article › Research › peer-review

Open Access

22 Citations (Scopus)
2019

AT1R-AT2R-RXFP1 functional crosstalk in myofibroblasts: Impact on the therapeutic targeting of renal and cardiac fibrosis
Chow, B. S. M., Kocan, M., Shen, M., Wang, Y., Han, L., Chew, J. Y., Wang, C., Bosnyak, S., Mirabito-Colafella, K. M., Barsha, G., Wigg, B., Johnstone, E. K. M., Hossain, M. A., Pfleger, K. D. G., Denton, K. M., Widdop, R. E., Summers, R. J., Bathgate, R. A. D., Hewitson, T. D. & Samuel, C. S., 1 Jan 2019, In: Journal of the American Society of Nephrology. 30, 11, p. 2191-2207 17 p.
Research output: Contribution to journal › Article › Research › peer-review

43 Citations (Scopus)
2017

Anti-fibrotic actions of relaxin
Samuel, C. S., Royce, S. G., Hewitson, T. D., Denton, K. M., Cooney, T. E. & Bennett, R. G., 1 May 2017, In: British Journal of Pharmacology. 174, 10, p. 962-976 15 p.
Research output: Contribution to journal › Review Article › Research › peer-review

110 Citations (Scopus)
Anti-fibrotic potential of AT₂ receptor agonists
Wang, Y., Del Borgo, M., Lee, H. W., Baraldi, D., Hirmiz, B., Gaspari, T. A., Denton, K. M., Aguilar, M.-I., Samuel, C. S. & Widdop, R. E., 31 Aug 2017, In: Frontiers in Pharmacology. 8, 7 p., 564.
Research output: Contribution to journal › Review Article › Research › peer-review

Open Access
File

83 Citations (Scopus)