Understanding the cardio-protective actions of the AT2R in females: Shifting gears between AT1 and AT2 receptor balance of function with relaxin.

Denton, Katherine (Primary Chief Investigator (PCI))
Samuel, Chrishan (Chief Investigator (CI))
Widdop, Robert (Chief Investigator (CI))
Hewitson, Timothy (Chief Investigator (CI))
Pearson, James (Chief Investigator (CI))

Project: Research

Status	Finished
Effective start/end date	1/01/16 → 31/12/19

Funding

National Health and Medical Research Council (NHMRC) (Australia): A$524,644.00
National Health and Medical Research Council (NHMRC) (Australia): A$524,644.00

5 Article
2 Review Article

In Aged Females, the Enhanced Pressor Response to Angiotensin II Is Attenuated By Estrogen Replacement via an Angiotensin Type 2 Receptor-Mediated Mechanism
Barsha, G., Mirabito Colafella, K. M., Walton, S. L., Gaspari, T. A., Spizzo, I., Pinar, A. A., Hilliard Krause, L. M., Widdop, R. E., Samuel, C. S. & Denton, K. M., Jul 2021, In: Hypertension. 78, 1, p. 128-137 10 p.
Research output: Contribution to journal › Article › Research › peer-review

12 Citations (Scopus)
Relaxin Attenuates Organ Fibrosis via an Angiotensin Type 2 Receptor Mechanism in Aged Hypertensive Female Rats
Barsha, G., Walton, S., Kwok, E., Mirabito Colafella, K. M., Pinar, A. A., Hilliard Krause, L. M., Gaspari, T. A., Widdop, R. E., Samuel, C. S. & Denton, K. M., Nov 2021, In: Kidney360. 2, 11, p. 1781-1792 12 p.
Research output: Contribution to journal › Article › Research › peer-review

Open Access

11 Citations (Scopus)
Serelaxin and the AT₂ Receptor Agonist CGP42112 Evoked a Similar, Nonadditive, Cardiac Antifibrotic Effect in High Salt-Fed Mice That Were Refractory to Candesartan Cilexetil
Wang, Y., Han, L., Shen, M., Jones, E. S., Spizzo, I., Walton, S. L., Denton, K. M., Gaspari, T. A., Samuel, C. S. & Widdop, R. E., 14 Feb 2020, In: ACS Pharmacology & Translational Science. 3, 1, p. 76-87 12 p.
Research output: Contribution to journal › Article › Research › peer-review

Open Access
File

15 Citations (Scopus)