Understanding pore formation by the complement Membrane Attack Complex

Project: Research

Project Description

The Membrane Attack Complex (MAC) is a large hole punching protein complex used by the human immune
system to target invading bacteria and parasites. The MAC is part of a superfamily of proteins, the MACPF/CDC
superfamily, used by animals (venoms/immunity), fungi for defense and by pathogenic bacteria in disease.
MACPF/CDC proteins play unknown roles in development, embryogenesis and neurobiology. This is a unique
class of proteins that function by punching giant holes in lipid membranes of target cells. The aim of this project is to image to the highest possible resolution how the MAC form pores in the context of
bacterial cells and explore the way it inserts into cells in real-time.
StatusActive
Effective start/end date30/06/1630/04/21

Funding

  • Australian Research Council (ARC): AUD704,960.00
  • Australian Research Council (ARC): AUD96,000.00
  • Monash University