The use of performance and image-enhancing drugs (PIEDs) is rising in Australia. PIED use is associated with a range of serious health issues, including the transmission of blood-borne viruses, especially hepatitis C (HCV), due to PIED injecting. Little is known about PIED injecting in Australia, and the nation's harm reduction framework is unprepared to meet the unique challenges it poses. This qualitative interview-based project will generate new knowledge on PIED use, the meanings and social practices associated with it, and the health information needs of PIED injectors. It will directly inform policy and practice, potentially helping to avert an epidemic of HCV in this hitherto neglected population of people who inject drugs.