Understanding novel drug binding pockets at G protein-coupled receptors

Valant, Celine (Primary Chief Investigator (PCI))

Drug Discovery Biology

Project: Research

Status	Finished
Effective start/end date	1/01/15 → 31/12/17

Funding

National Health and Medical Research Council (NHMRC) (Australia): A$412,077.00

4 Article

Ligand-directed biased agonism at human histamine H₃ receptor isoforms across Gα_i/o- and β-arrestin2-mediated pathways
Rahman, S. N., Imhaouran, F., Leurs, R., Christopoulos, A., Valant, C. & Langmead, C. J., Oct 2024, In: Biochemical Pharmacology. 228, 24 p., 115988.
Research output: Contribution to journal › Article › Research › peer-review

Open Access

2 Citations (Scopus)
Structure-based discovery of selective positive allosteric modulators of antagonists for the M₂ muscarinic acetylcholine receptor
Korczynska, M., Clark, M. J., Valant, C., Xu, J., Moo, E. V., Albold, S., Weiss, D. R., Torosyan, H., Huang, W., Kruse, A. C., Lyda, B. R., May, L. T., Baltos, J. A., Sexton, P. M., Kobilka, B. K., Christopoulos, A., Shoichet, B. K. & Sunahara, R. K., 6 Mar 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 10, p. E2419-E2428 10 p.
Research output: Contribution to journal › Article › Research › peer-review

Open Access
File

53 Citations (Scopus)
Utility of an "allosteric site-impaired" M₂ muscarinic acetylcholine receptor as a novel construct for validating mechanisms of action of synthetic and putative endogenous allosteric modulators
Moo, E. V., Sexton, P. M., Christopoulos, A. & Valant, C., 1 Nov 2018, In: Molecular Pharmacology. 94, 5, p. 1298-1309 12 p.
Research output: Contribution to journal › Article › Research › peer-review

4 Citations (Scopus)