Sexually distinct cardiovascular traits are conserved across mammalian species. Early developmental events are known to be important in influencing later adult characteristics - but how adult cardiovascular functions are 'programmed' so differently for males and females is not understood. The goal of this project is to track the influence of sex and sex hormones through crucial lifespan timepoints to define how specific patterns of gene signalling determine adult cardiovascular traits - at cell, tissue and systems level. The importance of the placenta in regulating fetus exposure to sex steroids and the crucial effects of the pubertal hormone surge in shaping cardiovascular phenotypes of male and female offspring will be uncovered.
|Effective start/end date||1/01/16 → 31/12/18|
- Australian Research Council (ARC)