Understanding mechanisms of allostery and biased agonism at the adenosine A1 receptor

Project: Research

Status	Finished
Effective start/end date	1/01/15 → 31/12/17

Recent advances in the determination of G protein-coupled receptor structures
Thal, D. M., Vuckovic, Z., Draper-Joyce, C. J., Liang, Y.-L., Glukhova, A., Christopoulos, A. & Sexton, P. M., 1 Aug 2018, In: Current Opinion in Structural Biology. 51, p. 28-34 7 p.
Research output: Contribution to journal › Article › Research › peer-review

53 Citations (Scopus)
Extracellular loop 2 of the adenosine A₁ receptor has a key role in orthosteric ligand affinity and agonist efficacy
Nguyen, A. T. N., Baltos, J.-A., Thomas, T., Nguyen, T. D., Lopez Munoz, L., Gregory, K. J., White, P. J., Sexton, P. M., Christopoulos, A. & May, L. T., 1 Dec 2016, In: Molecular Pharmacology. 90, 6, p. 703-714 12 p.
Research output: Contribution to journal › Article › Research › peer-review

43 Citations (Scopus)
Novel irreversible agonists acting at the A₁ adenosine receptor
Jorg, M., Glukhova, A., Abdul Ridha, A., Vecchio, E. A., Nguyen, A., Sexton, P., White, P., May, L., Christopoulos, A. & Scammells, P., 22 Dec 2016, In: Journal of Medicinal Chemistry. 59, 24, p. 11182-11194 13 p.
Research output: Contribution to journal › Article › Research › peer-review

20 Citations (Scopus)

Project Details