The project aims to determine to what extent and by which mechanisms T cells modulate tissue repair and regeneration in mammals. As models, we will use skin repair and bone regeneration in the mouse. Moreover, we seek to engineer a novel biomaterial platform for controlling the regenerative functions of T cells in vivo. Most of the mechanisms modulating the healing of injured tissues are still elusive, especially the role of the immune
response which always follows tissue injury. This research would reveal unknown mechanisms controlling the processes of tissue repair and regeneration, particularly the nexus between the stem cells that are involved in the tissue healing process and the immune response following tissue injury.