Research output per year
Research output per year
Project Details
Project Description
This project aims to investigate the molecular mechanism by which mitochondria divide. Mitochondria are the
powerhouse within our cells and they grow and divide in our cells to ensure that they are transferred to daughter
cells and also so that older mitochondria can be turned over. The study builds on the discovery made by the chief
investigators of mitochondrial membrane proteins that are involved in fission. The results of the project could
provide fundamental new knowledge into how the mitochondrial division machine assembles and how
mitochondrial fate is determined.
powerhouse within our cells and they grow and divide in our cells to ensure that they are transferred to daughter
cells and also so that older mitochondria can be turned over. The study builds on the discovery made by the chief
investigators of mitochondrial membrane proteins that are involved in fission. The results of the project could
provide fundamental new knowledge into how the mitochondrial division machine assembles and how
mitochondrial fate is determined.
| Status | Finished |
|---|---|
| Effective start/end date | 1/01/16 → 31/12/18 |
Funding
- Australian Research Council (ARC): A$433,300.00
- Monash University
-
Dynamin-related protein 1 has membrane constricting and severing abilities sufficient for mitochondrial and peroxisomal fission
Kamerkar, S. C., Kraus, F., Sharpe, A. J., Pucadyil, T. J. & Ryan, M. T., 7 Dec 2018, In: Nature Communications. 9, 1, 15 p., 5239.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile162 Citations (Scopus) -
The constriction and scission machineries involved in mitochondrial fission
Kraus, F. & Ryan, M. T., 2017, In: Journal of Cell Science. 130, 18, p. 2953-2960 8 p.Research output: Contribution to journal › Review Article › Research › peer-review
Open AccessFile184 Citations (Scopus) -
Cooperative and independent roles of Drp1 adaptors Mff and MiD49/51 in mitochondrial fission
Osellame, L. D., Singh, A. P., Stroud, D. A., Palmer, C. S., Stojanovski, D., Ramachandran, R. & Ryan, M. T., 2016, In: Journal of Cell Science. 129, 11, p. 2170-2181 12 p.Research output: Contribution to journal › Article › Research › peer-review
246 Citations (Scopus)