Understanding G Protein-coupled receptors (GPCRs): Accelerating discovery from concept to clinic

Sexton, Patrick (Primary Chief Investigator (PCI))
Christopoulos, Arthur (Chief Investigator (CI))
Summers, Roger (Chief Investigator (CI))

Pharmacology

Project: Research

Status	Finished
Effective start/end date	1/01/09 → 31/12/13

Funding

National Health and Medical Research Council (NHMRC) (Australia): A$4,551,055.50
National Health and Medical Research Council (NHMRC) (Australia): A$1,950,451.50

7 Article
2 Review Article

BRL37344 stimulates GLUT4 translocation and glucose uptake in skeletal muscle via β ₂ -adrenoceptors without causing classical receptor desensitization
Mukaida, S., Sato, M., Öberg, A. I., Dehvari, N., Olsen, J. M., Kocan, M., Halls, M. L., Merlin, J., Sandström, A. L., Csikasz, R. I., Evans, B. A., Summers, R. J., Hutchinson, D. S. & Bengtsson, T., 1 May 2019, In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 316, 5, p. R666-R677 12 p.
Research output: Contribution to journal › Article › Research › peer-review

Open Access
File

12 Citations (Scopus)
Rosiglitazone and a β₃-adrenoceptor agonist are both required for functional browning of white adipocytes in culture
Merlin, J., Sato, M., Chia, L. Y., Fahey, R., Pakzad, M., Nowell, C. J., Summers, R. J., Bengtsson, T., Evans, B. A. & Hutchinson, D. S., 30 May 2018, In: Frontiers in Endocrinology. 9, MAY, 17 p., 249.
Research output: Contribution to journal › Article › Research › peer-review

Open Access
File

25 Citations (Scopus)
Accelerated structure-based design of chemically diverse allosteric modulators of a muscarinic G protein-coupled receptor
Miao, Y., Goldfeld, D. A., Moo, E. V., Sexton, P. M., Christopoulos, A., McCammon, J. A. & Valant, C., 20 Sept 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 38, p. E5675-E5684 10 p.
Research output: Contribution to journal › Article › Research › peer-review

Open Access

76 Citations (Scopus)

Understanding G Protein-coupled receptors (GPCRs): Accelerating discovery from concept to clinic

Project Details

Funding

Research output

BRL37344 stimulates GLUT4 translocation and glucose uptake in skeletal muscle via β 2 -adrenoceptors without causing classical receptor desensitization

Rosiglitazone and a β3-adrenoceptor agonist are both required for functional browning of white adipocytes in culture

Accelerated structure-based design of chemically diverse allosteric modulators of a muscarinic G protein-coupled receptor

BRL37344 stimulates GLUT4 translocation and glucose uptake in skeletal muscle via β ₂ -adrenoceptors without causing classical receptor desensitization

Rosiglitazone and a β₃-adrenoceptor agonist are both required for functional browning of white adipocytes in culture