Understanding bias and allostery at the calcium sensing receptor

Project: Research

Project Description

This Proposal seeks to provide a mechanistic and dynamic picture of the structure, function and physiology of the human calcium sensing receptor (CaSR). The CaSR is critical for vertebrate life. By responding to varied chemicals in the body, it acts as a universal nutrient sensor to maintain extracellular calcium homeostasis and mediate many other biological functions, including neurotransmission, inflammation, digestion, blood pressure and development. However, it is not known how this single receptor controls the actions of multiple ligands to mediate numerous functions. By elucidating the significant roles of the CaSR and its ligands, this Proposal in turn aims to lay the foundations to understanding fundamental physiological processes
StatusActive
Effective start/end date1/01/1731/12/20

Funding

  • Australian Research Council (ARC): AUD591,448.00
  • Australian Research Council (ARC): AUD89,192.00
  • Monash University: AUD67,864.00