Understanding allosteric modulation and biased signalling at Family B GPCRs

Research output

Research output per year 2016 2016 2017 2018

• 6 Article
• 1 Review Article

Research output per year

Research output per year

Search results

• 2018

  Glucagon-like peptide-1 receptor internalisation controls spatiotemporal signalling mediated by biased agonists

  Fletcher, M. M., Halls, M. L., Zhao, P., Clydesdale, L., Christopoulos, A., Sexton, P. M. & Wootten, D., 1 Oct 2018, In: Biochemical Pharmacology. 156, p. 406-419 14 p.

  Research output: Contribution to journal › Article › Research › peer-review
  44 Citations (Scopus)
• 2017

  Coexpressed class B G protein-coupled secretin and GLP-1 receptors self- and cross-associate: impact on pancreatic islets

  Harikumar, K. G., Lau, S., Sexton, P. M., Wootten, D. & Miller, L. J., 1 Jun 2017, In: Endocrinology. 158, 6, p. 1685-1700 16 p.

  Research output: Contribution to journal › Article › Research › peer-review
  9 Citations (Scopus)

• Phase-plate cryo-EM structure of a class B GPCR-G-protein complex

  Liang, Y.-L., Khoshouei, M., Radjainia, M., Zhang, Y., Glukhova, A., Tarrasch, J., Thal, D., Furness, S. G. B., Christopoulos, G., Coudrat, T., Danev, R., Baumeister , W., Miller, L. J., Christopoulos, A., Kobilka, B., Wootten, D., Skiniotis, G. & Sexton, P., 1 Jun 2017, In: Nature. 546, 7656, p. 118-123 6 p.

  Research output: Contribution to journal › Article › Research › peer-review
  398 Citations (Scopus)

• Structural features embedded in G protein-coupled receptor co-crystal structures are key to their success in virtual screening

  Coudrat, T., Christopoulos, A., Sexton, P. M. & Wootten, D., 1 Apr 2017, In: PLoS ONE. 12, 4, 29 p., e0174719.

  Research output: Contribution to journal › Article › Research › peer-review

  File
  10 Citations (Scopus)
• 2016

  Glucagon-like peptide-1 and its class B G protein-coupled receptors: a long march to therapeutic successes

  de Graaf, C., Donnelly, D., Wootten, D., Lau, J., Sexton, P. M., Miller, L. J., Ahn, J.-M., Liao, J., Fletcher, M. M., Yang, D., Brown, A. J. H., Zhou, C., Deng, J. & Wang, M.-W., 1 Oct 2016, In: Pharmacological Reviews. 68, 4, p. 954-1013 60 p.

  Research output: Contribution to journal › Review Article › Research › peer-review
  285 Citations (Scopus)

• Key interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in the glucagon-like peptide-1 receptor

  Wootten, D., Reynolds, C. A., Smith, K. J., Mobarec, J. C., Furness, S. G. B., Miller, L. J., Christopoulos, A. & Sexton, P. M., 15 Oct 2016, In: Biochemical Pharmacology. 118, p. 68-87 20 p.

  Research output: Contribution to journal › Article › Research › peer-review
  38 Citations (Scopus)

• Ligand-dependent modulation of G protein conformation alters drug efficacy

  Furness, S. G. B., Liang, Y.-L., Nowell, C. J., Halls, M. L., Wookey, P. J., Dal Maso, E., Inoue, A., Christopoulos, A., Wootten, D. & Sexton, P. M., 20 Oct 2016, In: Cell. 167, 3, p. 739-749 11 p.

  Research output: Contribution to journal › Article › Research › peer-review
  106 Citations (Scopus)